ReviewMicrobiological reviews1995
Immune regulation in Epstein-Barr virus-associated diseases.
Review in Microbiological reviews, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 177 citations in OpenAlex.
- Autologous lymphokine-activated killer cell therapy of lymphoproliferative disorders arising in organ transplant recipients.Transplantation proceedings · 1997Trial
- Epstein-Barr virus (EBV)-associated smooth muscle tumor of the central nervous system in an HIV patient: diagnostic and therapeutic challenges.BMC infectious diseases · 2026Article
- Epstein-Barr virus-infected tonsillar marginal zone B cellsJournal of virology · 2025Article
- Review
- Loop-mediated isothermal amplification linked a nanoparticles-based biosensor for detecting Epstein-Barr virus.Applied microbiology and biotechnology · 2024Article
- Acute Presentation of Primary CNS Lymphoma Mimicking Toxoplasma in HIV Infection.Journal of community hospital internal medicine perspectives · 2023Article
- Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2018Article
- Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation.EBioMedicine · 2016Article
- Differential Recognition of Influenza A Viruses by M158-66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues.Journal of virology · 2016Article
- Association of Herpes Viruses with Mild, Moderate and Severe Chronic Periodontitis.Journal of clinical and diagnostic research : JCDR · 2015Article
- mRNA Structural constraints on EBNA1 synthesis impact on in vivo antigen presentation and early priming of CD8+ T cells.PLoS pathogens · 2014Article
- The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey.Infectious agents and cancer · 2014Review
- HIV Associated Intra-oral Burkitt's Lymphoma: A Case Report.Journal of clinical and diagnostic research : JCDR · 2013Article
- Cellular immune therapy for viral infections in transplant patients.The Indian journal of medical research · 2013Review
- Antineutrophil Cytoplasmic Autoantibody Associated Systemic Vasculitis Is Associated with Epstein - Barr virus in the Setting of HIV Infection.Infectious diseases in clinical practice (Baltimore, Md.) · 2013Article
- Incidence and trends in Burkitt lymphoma in northern Tanzania from 2000 to 2009.Pediatric blood & cancer · 2012Article
- Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma.Blood cancer journal · 2012Article
- Generating CTLs against the subdominant EBV LMP antigens by transient expression of an A20 inhibitor with EBV LMP proteins in human DCs.Gene therapy · 2012Article
- The Epstein-Barr Virus EBNA1 Protein.Scientifica · 2012Review
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Epstein-Barr virus (EBV) is a member of the human herpesvirus family and, like many other herpesviruses, maintains a lifelong latent association with B lymphocytes and a permissive association with stratified epithelium in the oropharynx. Clinical manifestations of primary EBV infection range from acute infectious mononucleosis to an asymptomatic persistent infection. EBV is also associated with a number of malignancies in humans. This review discusses features of the biology of the virus, both in cell culture systems and in the natural host, before turning to the role of the immune system in controlling EBV infection in healthy individuals and in individuals with EBV-associated diseases. Cytotoxic T cells that recognize virally determined epitopes on infected cells make up the major effector arm and control the persistent infection. In contrast, the options for immune control of EBV-associated malignancies are more restricted. Not only is antigen expression restricted to a single nuclear antigen, EBNA1, but also these tumor cells are unable to process EBV latent antigens, presumably because of a transcriptional defect in antigen-processing genes (such as TAP1 and TAP2). The likelihood of producing a vaccine capable of controlling the acute viral infection and EBV-associated malignancies is also discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.