ReviewMicrobiological reviews1995
Protein trafficking in kinetoplastid protozoa.
Review in Microbiological reviews, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 99 citations in OpenAlex.
- Manipulating and elucidating mitochondrial gene expression with engineered proteins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- In vivo analysis of trypanosome mitochondrial RNA function by artificial site-specific RNA endonuclease-mediated knockdown.RNA (New York, N.Y.) · 2015Article
- Trypanosome alternative oxidase possesses both an N-terminal and internal mitochondrial targeting signal.Eukaryotic cell · 2014Article
- Three distinct isoforms of ATP synthase subunit c are expressed in T. brucei and assembled into the mitochondrial ATP synthase complex.PloS one · 2013Article
- An Advanced System of the Mitochondrial Processing Peptidase and Core Protein Family in Trypanosoma brucei and Multiple Origins of the Core I Subunit in Eukaryotes.Genome biology and evolution · 2013Article
- Cloning and Expression of Leishmania infantum LPG3 Gene by the Lizard Leishmania Expression System.Avicenna journal of medical biotechnology · 2012Article
- TbPIF8, a Trypanosoma brucei protein related to the yeast Pif1 helicase, is essential for cell viability and mitochondrial genome maintenance.Molecular microbiology · 2012Article
- Immunobiology of African trypanosomes: need of alternative interventions.Journal of biomedicine & biotechnology · 2010Article
- Review
- Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.Parasitology research · 2006Review
- Functional complementation of RNA interference mutants in trypanosomes.BMC biotechnology · 2005Article
- Structural features of the lysosomal hydrolase mannose 6-phosphate uncovering enzyme.Glycoconjugate journal · 2005Article
- Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae.Molecular biology of the cell · 2004Article
- Rab5-mediated endosome-endosome fusion regulates hemoglobin endocytosis in Leishmania donovani.The EMBO journal · 2003Article
- Involvement of the endoplasmic reticulum in peroxisome formation.Molecular biology of the cell · 2003Article
- Extracellular metalloproteinase activity in Phytomonas françai.Parasitology research · 2003Article
- Plant-like traits associated with metabolism of Trypanosoma parasites.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Secretory pathway of trypanosomatid parasites.Microbiology and molecular biology reviews : MMBR · 2002Review
- Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.Journal of medicinal chemistry · 2001Article
- Sequence requirements for trafficking of the CRAM transmembrane protein to the flagellar pocket of African trypanosomes.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetoplastid protozoa infect hosts ranging from invertebrates to plants and mammals, causing diseases of medical and economic importance. They are the earliest-branching organisms in eucaryotic evolution to have either mitochondria or peroxisome-like microbodies. Investigation of their protein trafficking enables us to identify characteristics that have been conserved throughout eucaryotic evolution and also reveals how far variations, or alternative mechanisms, are possible. Protein trafficking in kinetoplastids is in many respects similar to that in higher eucaryotes, including mammals and yeasts. Differences in signal sequence specificities exist, however, for all subcellular locations so far examined in detail--microbodies, mitochondria, and endoplasmic reticulum--with signals being more degenerate, or shorter, than those of their higher eucaryotic counterparts. Some components of the normal array of trafficking mechanisms may be missing in most (if not all) kinetoplastids: examples are clathrin-coated vesicles, recycling receptors, and mannose 6-phosphate-mediated lysosomal targeting. Other aspects and structures are unique to the kinetoplastids or are as yet unexplained. Some of these peculiarities may eventually prove to be weak points that can be used as targets for chemotherapy; others may turn out to be much more widespread than currently suspected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.