ArticleMicrobial pathogenesis1995
Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells.
Article in Microbial pathogenesis, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection.Frontiers in pharmacology · 2021Review
- Murine coronavirus neuropathogenesis: determinants of virulence.Journal of neurovirology · 2010Review
- The murine coronavirus nucleocapsid gene is a determinant of virulence.Journal of virology · 2010Article
- Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent.Journal of virology · 2008Article
- Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies.The American journal of pathology · 2007Article
- Immunopathogenesis of coronavirus infections: implications for SARS.Nature reviews. Immunology · 2005Review
- Increased epitope-specific CD8+ T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination.Journal of virology · 2005Article
- Effects of an epitope-specific CD8+ T-cell response on murine coronavirus central nervous system disease: protection from virus replication and antigen spread and selection of epitope escape mutants.Journal of virology · 2004Article
- Differential regulation of innate and adaptive immune responses in viral encephalitis.Virology · 2004Article
- Virus demyelination.Journal of neurovirology · 2003Review
- Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59.Journal of neurovirology · 2002Article
- Murine hepatitis virus--a model for virus-induced CNS demyelination.Journal of neurovirology · 2002Review
- Viral induced demyelination.Brain pathology (Zurich, Switzerland) · 2001Review
- Coronavirus-induced membrane fusion requires the cysteine-rich domain in the spike protein.Virology · 2000Article
- Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism.Journal of virology · 1998Article
- Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus.Journal of virology · 1998Article
- Rational approaches to immune regulation.Immunologic research · 1998Review
- Article
- Murine coronavirus infection: a paradigm for virus-induced demyelinating disease.Trends in microbiology · 1997Review
- Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.Journal of virology · 1997Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mouse hepatitis virus causes a chronic demyelinating disease in C57BL/6 mice. While early studies suggested demyelination is due to direct cytolytic effects of virus on oligodendrocytes, there is increasing evidence for the involvement of the immune system in the mechanism of demyelination. In this study we have asked whether demyelination can occur in the absence of functional MHC class I expression and CD8+ T cells. We infected transgenic mice lacking expression of beta 2 microglobulin (beta 2 M -/- mice) with MHV-A59. In beta 2M-/- mice, virus was much more lethal than in either of the parental strains used to produce the mice; furthermore, while clearance from the CNS did occur in beta 2M-/- mice, it was slower than in C57BL/6 mice. This is consistent with the importance of CD8+ cells in viral clearance. Because of the increased sensitivity of the beta 2M-/- mice to infection, only low levels of virus could be used to evaluate chronic disease. Even at these low levels, demyelination did occur in some animals. To compare infection in beta 2M-/- and C57BL/6 mice we used a higher dose of an attenuated variant of MHV-A59, C12. The attenuated variant induced less demyelination in C57BL/6 mice compared to wild type A59, but the levels observed were not significantly different from those seen in beta 2M-/- mice. Thus, MHV-induced demyelination can occur in some animals in the absence of MHC class I and CD8+ cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.