ArticleJournal of molecular evolution1995
A Drosophila hsp70 gene contains long, antiparallel, coupled open reading frames (LAC ORFs) conserved in homologous loci.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 30 citations in OpenAlex.
- The chromosomes of Drosophila suzukii (Diptera: Drosophilidae): detailed photographic polytene chromosomal maps and in situ hybridization data.Molecular genetics and genomics : MGG · 2019Article
- Dystrophin gene expression and intracellular calcium changes in the giant freshwater prawn,Heliyon · 2017Article
- Detection of functional overlapping genes: simulation and case studies.Journal of molecular evolution · 2010Article
- Article
- Open reading frames provide a rich pool of potential natural antisense transcripts in fungal genomes.Nucleic acids research · 2005Article
- The heat shock genes in the Drosophila montium subgroup: chromosomal localization and evolutionary implications.Chromosoma · 1996Article
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7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A clone isolated from a Drosophila auraria heat-shock cDNA library presents two long, antiparallel, coupled (LAC) open reading frames (ORFs). One strand ORF is 1,929 nucleotides long and exhibits great identity (87.5% at the nucleotide level and 94% at the amino acid level) with the hsp70 gene copies of D. melanogaster, while the second strand ORF, in antiparallel in-frame register arrangement, is 1,839 nucleotides long and exhibits 32% identity with a putative, recently identified, NAD(+)-dependent glutamate dehydrogenase (NAD(+)-GDH). The overlap of the two ORFs is 1,824 nucleotides long. Computational analysis shows that this LAC ORF arrangement is conserved in other hsp70 loci in a wide range of organisms, raising questions about possible evolutionary benefits of such a peculiar genomic organization.
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