ArticleThe Journal of physiology1995
Spontaneous, ligand-independent activity of the cGMP-gated ion channels in cone photoreceptors of fish.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.Investigative ophthalmology & visual science · 2012Article
- RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel.Advances in experimental medicine and biology · 2010Article
- Thermodynamics of activation gating in olfactory-type cyclic nucleotide-gated (CNGA2) channels.Biophysical journal · 2008Article
- Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice.Journal of neurochemistry · 2008Article
- Activation of olfactory-type cyclic nucleotide-gated channels is highly cooperative.The Journal of physiology · 2005Article
- Activation of olfactory cyclic-nucleotide gated channels revisited.The Journal of physiology · 2005Article
- Spontaneous channel activity of the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Application of allosteric modeling to calcium and InsP3 regulation of InsP3R single-channel gating.The Journal of general physiology · 2003Article
- Contribution of cyclic-nucleotide-gated channels to the resting conductance of olfactory receptor neurons.Biophysical journal · 2003Article
- Effects of ultraviolet modification on the gating energetics of cyclic nucleotide-gated channels.The Journal of general physiology · 2000Article
- The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.Biophysical journal · 2000Article
- Coexpression of alpha and beta subunits of the rod cyclic GMP-gated channel restores native sensitivity to cyclic AMP: role of D604/N1201.Biophysical journal · 2000Article
- Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.Biophysical journal · 2000Article
- Opening mechanism of a cyclic nucleotide-gated channel based on analysis of single channels locked in each liganded state.The Journal of general physiology · 1999Article
- High-gain, low-noise amplification in olfactory transduction.Biophysical journal · 1997Article
- Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors.Experientia · 1996Review
- Subunit interactions in the activation of cyclic nucleotide-gated ion channels.Biophysical journal · 1996Article
- Permeability and interaction of Ca2+ with cGMP-gated ion channels differ in retinal rod and cone photoreceptors.Biophysical journal · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We studied the electrical conductance of membrane patches detached from the outer segment of single cone photoreceptors isolated from striped bass retina. 2. Only a single class of ion channels exists in the plasma membrane of the cone outer segments; they are gated by cytoplasmic cGMP and select cations over anions, but distinguish poorly among cations. In the absence of added cGMP and of divalent cations, however, membrane patches detached from the outer segments exhibit a small conductance that ideally selects cations over anions, but distinguishes poorly between Na+ and Li+. 3. The cGMP-independent conductance does not arise from the effect of residual cGMP that may remain associated with the detached membrane, because treatment of the patch with cGMP-specific phosphodiesterase does not affect this conductance. 4. The cGMP-independent conductance is pharmacologically indistinguishable from that activated by cGMP. Ca2+ and L-cis-diltiazem block both conductances at comparable concentrations and with similar quantitative characteristics. 5. We analysed the noise of Ca(2+)- or L-cis-diltiazem-dependent macroscopic currents both in the presence and in the absence of cGMP. In the presence of cGMP, the power density spectrum of the noise is well fitted by the sum of two Lorentzian components. The same function with similar corner frequencies fits the noise of the cGMP-independent currents. However, the total power in the current fluctuations is smaller in the absence of cGMP than in its presence; also, the ratio of the zero frequency asymptotes of the low over the high frequency components, S1(0)/Sh(0), is larger in the absence of cGMP than in its presence.(ABSTRACT TRUNCATED AT 250 WORDS)
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