ArticleThe Journal of experimental medicine1995
Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 192 citations in OpenAlex.
- The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling.The Journal of cell biology · 2022Article
- Kinase inhibition in autoimmunity and inflammation.Nature reviews. Drug discovery · 2021Review
- Syk facilitates phagosome-lysosome fusion by regulating actin-remodeling in complement-mediated phagocytosis.Scientific reports · 2020Article
- Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.Haematologica · 2018Article
- PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation.The Journal of cell biology · 2018Article
- PLCγ2 promotes apoptosis while inhibits proliferation in rat hepatocytes through PKCD/JNK MAPK and PKCD/p38 MAPK signalling.Cell proliferation · 2018Article
- Characterization and expression analysis of Calmodulin (CaM) in orange-spotted grouper (Epinephelus coioides) in response to Vibrio alginolyticus challenge.Ecotoxicology (London, England) · 2015Article
- Rac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.The Journal of biological chemistry · 2015Article
- PDK1 controls upstream PI3K expression and PIP3 generation.Oncogene · 2014Article
- New insights into the DT40 B cell receptor cluster using a proteomic proximity labeling assay.The Journal of biological chemistry · 2014Article
- Negative selection of self-reactive chicken B cells requires B cell receptor signaling and is independent of the bursal microenvironment.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase.Cellular signalling · 2012Article
- Defense activation triggers differential expression of phospholipase-C (PLC) genes and elevated temperature induces phosphatidic acid (PA) accumulation in tomato.Plant signaling & behavior · 2012Article
- Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level.Frontiers in cellular and infection microbiology · 2012Article
- S-glutathionylation activates STIM1 and alters mitochondrial homeostasis.The Journal of cell biology · 2010Article
- BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation.The Journal of biological chemistry · 2009Article
- Glycosylphosphatidylinositol-anchored arginine-specific ADP-ribosyltransferase7.1 (Art7.1) on chicken B cells: the possible role of Art7 in B cell receptor signalling and proliferation.Molecular and cellular biochemistry · 2009Article
- TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action.The Journal of biological chemistry · 2008Article
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3 authors at 1 institution in 1 country.
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Abstract
Surface IgM (sIgM) stimulation induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C (PLC)-gamma 2, which is involved in the activation of phosphatidylinositol pathway. DT40 B cells underwent apoptotic cell death when activated through sIgM, a phenomenon that is related to elimination of self-reactive B cells. To examine the roles of PLC-gamma 2 in sIgM signaling, we have generated DT40 cells deficient in PLC-gamma 2 Cross-linking of sIgM on PLC-gamma 2-deficient cells evoked neither inositol 1,4,5-trisphosphate nor calcium mobilization. In PLC-gamma 2- or Syk-deficient DT40 cells, the induction of apoptosis was blocked, but was still observed in Lyn-deficient cells. Src homology 2 domains of PLC-gamma 2 were essential for both its activation and sIgM-induced apoptosis. Since tyrosine phosphorylation of PLC-gamma 2 is mediated by Syk, these results indicate that activation of PLC-gamma 2 through Syk is required for sIgM-induced apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.