ArticleThe Journal of experimental medicine1995
Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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Who cites it
79 citing papers in PubMed, 255 citations in OpenAlex.
- Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine.International journal of molecular sciences · 2022Review
- Review
- Phosphoproteomic Analysis of Rat Neutrophils Shows the Effect of Intestinal Ischemia/Reperfusion and Preconditioning on Kinases and Phosphatases.International journal of molecular sciences · 2020Article
- FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions.Biomolecules · 2020Review
- Role of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma and Its Therapeutic Prospect.OncoTargets and therapy · 2020Review
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- Article
- EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment.International journal of molecular sciences · 2017Review
- Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells.The Journal of biological chemistry · 2017Article
- Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.BMC cell biology · 2016Article
- In-situ coupling between kinase activities and protein dynamics within single focal adhesions.Scientific reports · 2016Article
- FAK and paxillin, two potential targets in pancreatic cancer.Oncotarget · 2016Review
- Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains.Journal of cell science · 2016Article
- Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.Biochemistry · 2016Article
- Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.The Journal of biological chemistry · 2015Article
- Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis.Arthritis research & therapy · 2014Article
- Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.Journal of cell science · 2014Article
- Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.Molecular and cellular biology · 2014Article
- Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1.Molecular and cellular biology · 2013Article
- In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by Src kinase.Biochemistry · 2012Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Focal adhesion kinase (pp125FAK) is localized to focal adhesions and tyrosine phosphorylated by the engagement of beta 1 integrins. However, it is unclear how pp125FAK is linked to integrin molecules. We demonstrate that pp125FAK is directly associated with paxillin, a 68-kD cytoskeleton protein. The COOH-terminal domain of pp125FAK spanning FAK residues 919-1042 is sufficient for paxillin binding and has vinculin-homologous amino acids, which are essential for paxillin binding. Microinjection and subsequent immunohistochemical analysis reveal that glutathione S-transferase-FAK fusion proteins, which bind to paxillin, localize to focal adhesions, whereas fusion proteins with no paxillin-binding activity do not localize to focal adhesions. These findings strongly suggest that pp125FAK is localized to focal adhesions by the direct association with paxillin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.