ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology1995
Effects of physical exercise and aging on ascorbic acid and superoxide anion levels in peritoneal macrophages from mice and guinea pigs.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 19 citations in OpenAlex.
- Overload training inhibits phagocytosis and ROS generation of peritoneal macrophages: role of IGF-1 and MGF.European journal of applied physiology · 2013Article
- Effects of endotoxic shock in several functions of murine peritoneal macrophages.Molecular and cellular biochemistry · 1998Article
- Effect of polar glycopeptidolipids from Mycobacterium chelonae (GPLp-Mc) on phagocytosis and superoxide anion production of macrophages from mice. Influence of physical activity.Molecular and cellular biochemistry · 1998Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship of physical activity and aging, two processes with a high production of oxygen-free radicals to the ascorbate and superoxide anion (O2-) contents of peritoneal macrophages was studied in two animals species: guinea-pig (in which ascorbic acid is a vitamin) and mouse (in which ascorbic acid is not a vitamin). The effects of exhaustive exercise were examined in young and old animals. The results show that macrophages from old animals have a lower ascorbate content than those from young ones, whereas with exercise the ascorbate content increased in both old and young animals. This increase was higher in young than in old animals, and more evident in mice than in guinea-pigs. Aging also resulted in an increase in the O2- levels of macrophages. With exercise these levels decreased in young mice but increased in young guinea-pigs. In old animals the exhaustive exercise did not change the O2- levels. The results suggest in general a lack of correlation between the intracellular ascorbate and O2- levels in relation to both physical exercise and aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.