ArticleThe Journal of clinical investigation1995
Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 167 citations in OpenAlex.
- Parental history of myocardial infarction and risk of heart failure in male physicians.European journal of clinical investigation · 2008Trial
- Establishing the hybrid rat diversity program: a resource for dissecting complex traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Research on Experimental Hypertension in Prague (1966-2009).Physiological research · 2024Article
- Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction.Journal of the American Heart Association · 2018Article
- Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits.Biophysical reviews · 2018Review
- Genetics of hypertension: an assessment of progress in the spontaneously hypertensive rat.Physiological genomics · 2017Review
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Genetic implication of a novel thiamine transporter in human hypertension.Journal of the American College of Cardiology · 2014Article
- Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats.Pflugers Archiv : European journal of physiology · 2013Article
- Integrative genomics in cardiovascular medicine.Cardiovascular research · 2013Review
- Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice.The Journal of clinical investigation · 2012Article
- CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.Physiological genomics · 2012Article
- Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.Physiological genomics · 2011Article
- Small RNA expression and strain specificity in the rat.BMC genomics · 2010Article
- Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.Nature genetics · 2008Article
- Genome-wide co-expression analysis in multiple tissues.PloS one · 2008Article
- Article
- Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Functional genomics in rodent models of hypertension.The Journal of physiology · 2004Review
- A new framework marker-based linkage map and SDPs for the rat HXB/BXH strain set.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 6 countries.
Funding
Abstract
In the HXB and BXH recombinant inbred strains derived from the spontaneously hypertensive rat and the normotensive Brown Norway rat, we determined the strain distribution patterns of 500 genetic markers to scan the rodent genome for quantitative trait loci regulating cardiac mass and blood pressure. The markers spanned approximately 1,139 cM of the genome and were tested for correlations with left ventricular mass adjusted for body weight, and with systolic, diastolic, and mean arterial pressures. The marker for the dopamine 1A receptor (Drd1a) on chromosome 17 showed the strongest correlation with left ventricular heart weight (P = .00038, r = -0.59) and the relationship to heart weight was independent of blood pressure. The markers showing the strongest correlations with systolic, diastolic, and mean arterial pressure were D19Mit7 on chromosome 19 (P = .0012, r = .55), D2N35 on chromosome 2 (P = .0008, r = .56), and Il6 on chromosome 4 (P = .0018, r = .53), respectively. These studies demonstrate that the HXB and BXH strains can be effectively used for genome scanning studies of complex traits and have revealed several chromosome regions that may be involved in the genetic control of blood pressure and cardiac mass in the rat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.