ArticleJournal of clinical immunology1995
Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes.
Article in Journal of clinical immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- AIRE deficiency, from preclinical models to human APECED disease.Disease models & mechanisms · 2021Review
- MicroRNA-26a/b have protective roles in oral lichen planus.Cell death & disease · 2020Article
- Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality.Frontiers in immunology · 2018Article
- Thymic function in the regulation of T cells, and molecular mechanisms underlying the modulation of cytokines and stress signaling (Review).Molecular medicine reports · 2017Review
- PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2016Article
- Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall.Virchows Archiv : an international journal of pathology · 2014Article
- IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.Nature communications · 2014Article
- TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.International immunology · 2013Article
- Thymic self-antigen expression for the design of a negative/tolerogenic self-vaccine against type 1 diabetes.Clinical & developmental immunology · 2011Article
- Murine mCLCA5 is expressed in granular layer keratinocytes of stratified epithelia.Histochemistry and cell biology · 2010Article
- Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.The Journal of experimental medicine · 2008Article
- Article
- R5 human immunodeficiency virus type 1 infection of fetal thymic organ culture induces cytokine and CCR5 expression.Journal of virology · 2005Article
- Immunolocalisation of the janus kinases (JAK)--signal transducers and activators of transcription (STAT) pathway in human epidermis.Journal of anatomy · 2001Article
- Laminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrins.The Journal of cell biology · 1999Article
- Medullary thymic epithelium: a mosaic of epithelial "self"?The Journal of experimental medicine · 1998Article
- Regulation of mucosal immune responses: distinct antigens and antigen presenting cells.Journal of clinical immunology · 1997Review
- Laminin chains in the basement membranes of human thymus.The Histochemical journal · 1996Article
- Developing stratified epithelia: lessons from the epidermis and thymus.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cellular interactions between developing thymocytes and cells of the thymic microenvironment are necessary for maturation of thymocytes into mature T cells. While much is known about the molecules on developing T cells that mediate these interactions, little is known about the surface molecules of human thymic epithelial (TE) cells. In this study, using a panel of 276 MAb including 255 MAb from the 5th International Workshop on Human Leukocyte Differentiation Antigens (HLDA-V), we have determined the expression of CD1 through CDw130 and other surface molecules on resting and IFN-gamma-activated cultured human TE cells and on resting epidermal keratinocytes (EK). We demonstrate the surface expression of 50 of the 161 molecules assayed for on TE cells, including a number of adhesion molecules, cytokine receptors, Apo-1, and MHC-encoded molecules. While activation of TE cells with IFN-gamma for 48 hr induced a greater than fivefold increase in the expression of four surface molecules (CD38, CD54, MHC class I, and MHC class II), it also induced a greater than 50% increase in the expression of 14 other surface molecules (CD12, CD29, CD40, CD44, CD47, CD49b, CD49c, CD49e, CD55, CD66, CD87, CD104, TE4, and STE3) and a decrease in the expression of three molecules (CDw65, CDw109, and STE2). In comparing the phenotype of TE cells to 83 other cell lines studied in HLDA-V, we found that TE cells were strikingly more similar to EK than to any of the other cell types tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.