ArticleThe Journal of cell biology1995
Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.The Journal of cell biology · 2022Article
- NgCAM and VAMP2 reveal that direct delivery and dendritic degradation maintain axonal polarity.Molecular biology of the cell · 2022Article
- Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Article
- Directional transneuronal spread of α-herpesvirus infection.Future virology · 2009Article
- Uncovering multiple axonal targeting pathways in hippocampal neurons.The Journal of cell biology · 2003Article
- Dynamics of glycine receptor insertion in the neuronal plasma membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Large scale transient 5-HT3 receptor production with the Semliki Forest Virus Expression System.Cytotechnology · 2000Article
- Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells.The Journal of cell biology · 1998Article
- Neuronal polarity: essential role of protein-lipid complexes in axonal sorting.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Inhibition of axonal growth by brefeldin A in hippocampal neurons in culture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Dendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps.The Journal of cell biology · 1997Article
- Assembly of GABAA receptors composed of alpha1 and beta2 subunits in both cultured neurons and fibroblasts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- ADP ribosylation factor 1 is required for synaptic vesicle budding in PC12 cells.The Journal of cell biology · 1997Article
- The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.The EMBO journal · 1996Article
- Subcellular localization of gamma-aminobutyric acid type A receptors is determined by receptor beta subunits.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Certain epithelial cells synthesize the polymeric immunoglobulin receptor (pIgR) to transport immunoglobulins (Igs) A and M into external secretions. In polarized epithelia, newly synthesized receptor is first delivered to the basolateral plasma membrane and is then, after binding the Ig, transcytosed to the apical plasma membrane, where the receptor-ligand complex is released by proteolytic cleavage. In a previous work (Ikonen et al., 1993), we implied the existence of a dendro-axonal transcytotic pathway for the rabbit pIgR expressed in hippocampal neurons via the Semliki Forest Virus (SFV) expression system. By labeling surface-exposed pIgR in live neuronal cells, we now show (a) internalization of the receptor from the dendritic plasma membrane to the dendritic early endosomes, (b) redistribution of the receptor from the dendritic to the axonal domain, (c) inhibition of this movement by brefeldin A (BFA) and (d) stimulation by the activation of protein kinase C (PKC) via phorbol myristate acetate (PMA). In addition, we show that a mutant form of the receptor lacking the epithelial basolateral sorting signal is directly delivered to the axonal domain of hippocampal neurons. Although this mutant is internalized into early endosomes, no transcytosis to the dendrites could be observed. In epithelial Madin-Darby Canine Kidney (MDCK) cells, the mutant receptor could also be internalized into basolaterally derived early endosomes. These results suggest the existence of a dendro-axonal transcytotic pathway in neuronal cells which shares similarities with the basolateral to apical transcytosis in epithelial cells and constitute the basis for the future analysis of its physiological role.
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