ArticleThe Journal of cell biology1995
ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Acetylcholine in Brain-Body Communication: Biological Mechanisms and Physiological Roles.International journal of molecular sciences · 2026Review
- Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity.Frontiers in physiology · 2020Review
- Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction.Developmental neurobiology · 2011Review
- Neuregulin-1 at synapses on phrenic motoneurons.The Journal of comparative neurology · 2010Article
- Molecular and cellular characterization of Neuregulin-1 type IV isoforms.Journal of neurochemistry · 2010Article
- Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions.Brain research · 2009Article
- Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Multiple personalities of neuregulin gene family members.The Journal of comparative neurology · 2004Review
- Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Essential roles of c-JUN and c-JUN N-terminal kinase (JNK) in neuregulin-increased expression of the acetylcholine receptor epsilon-subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Processing of ARIA and release from isolated nerve terminals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Review
- Synapse-specific and neuregulin-induced transcription require an ets site that binds GABPalpha/GABPbeta.Genes & development · 1998Article
- Agrin can mediate acetylcholine receptor gene expression in muscle by aggregation of muscle-derived neuregulins.The Journal of cell biology · 1998Article
- Activation of ErbB2 during wallerian degeneration of sciatic nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
ARIA is a member of a family of polypeptide growth and differentiation factors that also includes glial growth factor (GGF), neu differentiation factor, and heregulin. ARIA mRNA is expressed in all cholinergic neurons of the central nervous systems of rats and chicks, including spinal cord motor neurons. In vitro, ARIA elevates the rate of acetylcholine receptor incorporation into the plasma membrane of primary cultures of chick myotubes. To study whether ARIA may regulate the synthesis of junctional synaptic acetylcholine receptors in chick embryos, we have developed riboprobes and polyclonal antibody reagents that recognize isoforms of ARIA that include an amino-terminal immunoglobulin C2 domain and examined the expression and distribution of ARIA in motor neurons and at the neuromuscular junction. We detected significant ARIA mRNA expression in motor neurons as early as embryonic day 5, around the time that motor axons are making initial synaptic contacts with their target muscle cells. In older embryos and postnatal animals, we found ARIA protein concentrated in the synaptic cleft at neuromuscular junctions, consistent with transport down motor axons and release at nerve terminals. At high resolution using immunoelectron microscopy, we detected ARIA immunoreactivity exclusively in the synaptic basal lamina in a pattern consistent with binding to synapse specific components on the presynaptic side of the basal lamina. These results support a role for ARIA as a trophic factor released by motor neuron terminals that may regulate the formation of mature neuromuscular synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.