ArticleThe Journal of cell biology1995
A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Upregulation of Sortilin, a Lysosomal Sorting Receptor, Corresponds with Reduced Bioavailability of Latent TGFβ in Mucolipidosis II Cells.Biomolecules · 2020Article
- Secretory granule membrane protein recycles through multivesicular bodies.Traffic (Copenhagen, Denmark) · 2010Article
- Review
- Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated.Molecular biology of the cell · 2006Article
- Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.The Journal of biological chemistry · 2006Article
- Rab9 GTPase regulates late endosome size and requires effector interaction for its stability.Molecular biology of the cell · 2004Article
- The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.Molecular biology of the cell · 2004Article
- Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.The Journal of cell biology · 2004Article
- Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.Molecular biology of the cell · 2001Article
- Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor.Molecular biology of the cell · 2000Article
- Chimeric forms of furin and TGN38 are transported with the plasma membrane in the trans-Golgi network via distinct endosomal pathways.The Journal of cell biology · 1999Article
- Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain.Molecular biology of the cell · 1998Article
- A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Herpes simplex virus gD and virions accumulate in endosomes by mannose 6-phosphate-dependent and -independent mechanisms.Journal of virology · 1998Article
- Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment.The Journal of cell biology · 1998Article
- Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting.The Journal of cell biology · 1997Article
- Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Cloning and subcellular location of an Arabidopsis receptor-like protein that shares common features with protein-sorting receptors of eukaryotic cells.Plant physiology · 1997Article
- Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells.Molecular biology of the cell · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The bovine cation-dependent mannose 6-phosphate receptor (CD-MPR) is a type 1 transmembrane protein that cycles between the trans-Golgi network, endosomes, and the plasma membrane. When the terminal 40 residues were deleted from the 67-amino acid cytoplasmic tail of the CD-MPR, the half-life of the receptor was drastically decreased and the mutant receptor was recovered in lysosomes. Analysis of additional cytoplasmic tail truncation mutants and alanine-scanning mutants implicated amino acids 34-39 as being critical for avoidance of lysosomal degradation. The cytoplasmic tail of the CD-MPR was partially effective in preventing the lysosomal membrane protein Lamp1 from entering lysosomes. Complete exclusion required both the CD-MPR cytoplasmic tail and transmembrane domain. The transmembrane domain alone had just a minor effect on the distribution of Lamp1. These findings indicate that the cytoplasmic tail of the CD-MPR contains a signal that prevents the receptor from trafficking to lysosomes. The transmembrane domain of the CD-MPR also contributes to this function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.