ArticleJournal of cancer research and clinical oncology1995
Renal carcinogenesis in the Eker rat.
Article in Journal of cancer research and clinical oncology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- ERC/Mesothelin Is Associated with the Formation of Microvilli on the Mesothelium and Has Limited Functional Relevance Under Physiological Conditions.International journal of molecular sciences · 2025Article
- Serum Levels of N- and C-ERC/Mesothelin and Clinicopathological Factors in Mesothelioma Patients and Those without Mesothelioma.Juntendo Iji zasshi = Juntendo medical journal · 2023Article
- Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression.Respiratory research · 2020Article
- In commemoration of the 2018 Mataro Nagayo Prize: A road to early diagnosis and monitoring of asbestos-related mesothelioma.Cancer science · 2019Review
- Environmental carcinogenesis - 100th anniversary of creating cancer.Cancer science · 2015Review
- Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma.Cancer medicine · 2014Article
- Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer.PloS one · 2014Article
- ERC/mesothelin is expressed in human gastric cancer tissues and cell lines.Oncology reports · 2014Article
- Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma.Molecular and clinical oncology · 2014Article
- The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma.Journal of thoracic disease · 2013Article
- The utility of serum N-ERC/mesothelin as a biomarker of ovarian carcinoma.Oncology letters · 2012Article
- Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo.Cancer science · 2010Article
- Establishment of a novel specific ELISA system for rat N- and C-ERC/mesothelin. Rat ERC/mesothelin in the body fluids of mice bearing mesothelioma.Cancer science · 2008Article
- Diagnostic tumor marker of asbestos-related mesothelioma.Environmental health and preventive medicine · 2008Article
- Diagnostic biomarker of asbestos-related mesothelioma: example of translational research.Cancer science · 2007Review
- Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin.Cancer science · 2007Article
- Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients.Cancer science · 2006Article
- Renal carcinogenesis: genotype, phenotype and dramatype.Cancer science · 2003Review
- A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.Japanese journal of cancer research : Gann · 2000Article
- Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.The American journal of pathology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Eker rat hereditary renal carcinoma is an excellent example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We recently reported that a germline insertion in the rat homologue of the human tuberous sclerosis (TSC2) gene gives rise to the dominantly inherited cancer in the Eker rat model. The function of the TSC2/Tsc2 gene product (called "tuberine" in the human case) is not yet understood, although it contains a short amino acid sequence homologous to the ras family GTPase-activating proteins (GAP3). In the study, we isolated subtracted cDNA clones having increased expression in Eker renal carcinoma cells, using a modified representational difference analysis method to search for additional genes specifically involved in renal carcinogenesis. Here we identified four genes: the third component of the complement (C3) gene, the fos-related antigen I (fra-1) gene, an unknown gene (designated as being expressed in renal carcinoma: erc) and the calpactine I heavy-chain (Annexin II) gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.