ArticleInfection and immunity1995
Preferential induction of septic arthritis and mortality by superantigen-producing staphylococci.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Bacterial and host interactions inFrontiers in microbiology · 2025Review
- Novel therapeutic interventions towards improved management of septic arthritis.BMC musculoskeletal disorders · 2021Review
- The Immunomodulatory Effect ofThe open microbiology journal · 2017Article
- Septic arthritis: immunopathogenesis, experimental models and therapy.The journal of venomous animals and toxins including tropical diseases · 2014Review
- Differential arthritogenicity of Staphylococcus aureus strains isolated from biological samples.BMC infectious diseases · 2013Article
- Community-Associated Methicillin-Resistant Staphylococcus aureus Lacking PVL, as a Cause of Severe Invasive Infection Treated with Linezolid.Case reports in pediatrics · 2013Article
- Response of T-cell subpopulations to superantigen and recall antigen stimulation in systemic sclerosis.Indian journal of dermatology · 2012Article
- Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice.Arthritis research & therapy · 2012Article
- Possible protective role of chloramphenicol in TSST-1 and coagulase-positive Staphylococcus aureus-induced septic arthritis with altered levels of inflammatory mediators.Inflammation · 2011Article
- Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Interaction of staphylococci with bone.International journal of medical microbiology : IJMM · 2010Review
- Bacterial and Lyme Arthritis.Current infectious disease reports · 2004Article
- Acute septic arthritis.Clinical microbiology reviews · 2002Review
- Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome.Clinical microbiology reviews · 1999Review
- Review
- Role of the staphylococcal accessory gene regulator (sar) in septic arthritis.Infection and immunity · 1996Article
- Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia.Infection and immunity · 1996Article
- Role of superantigens in experimental arthritis.Springer seminars in immunopathology · 1996Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcal enterotoxins A through D (SEA through SED) and toxic shock syndrome toxin-1 display superantigen properties, i.e., they stimulate a great fraction of T cells expressing certain T-cell receptor V beta sequences. Using a newly established rat model of septic Staphylococcus aureus arthritis, we have recently shown that an S. aureus strain producing SEA showed marked arthritogenic properties. In the present study we decided to employ another five S. aureus strains, each one producing a distinct exotoxin. Almost all rats injected with superantigen-producing strains developed arthritis. In contrast, only 20% of rats injected with an S. aureus strain lacking superantigen production displayed mild and transient arthritis. Mortality was preferentially induced among the rats inoculated with the S. aureus strains producing SEB and SED. This study emphasizes that superantigen production is an important virulence factor in the development of septic S. aureus arthritis. Differences concerning mortality between staphylococcal strains producing different exotoxins may be dependent on the degree of activation of the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.