ArticleInfection and immunity1995
Endogenous interleukin-12 is involved in resistance of mice to Mycobacterium avium complex infection.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection againstVirulence · 2022Article
- A Rhesus Macaque Model of Pulmonary Nontuberculous Mycobacterial Disease.American journal of respiratory cell and molecular biology · 2016Article
- Article
- Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice.Infection and immunity · 2008Article
- Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium.Infection and immunity · 2007Article
- Pathogenesis of Mycobacterium avium infection: typical responses to an atypical mycobacterium?Immunologic research · 2006Review
- Article
- Interleukin-12 primes CD4+ T cells for interferon-gamma production and protective immunity during Mycobacterium avium infection.Immunology · 2001Article
- Non-major histocompatibility complex control of antibody isotype and Th1 versus Th2 cytokines during experimental infection of mice with Mycobacterium avium.Infection and immunity · 2001Article
- Induction of in vivo resistance to Mycobacterium avium infection by intramuscular injection with DNA encoding interleukin-18.Immunology · 2001Article
- Interaction of Mycobacterium avium with human monocyte-derived dendritic cells.Infection and immunity · 2000Article
- T lymphocytes from granulocyte colony-stimulating factor-/- mice produce large quantities of interferon-gamma in a chronic infection model.Immunology · 2000Article
- Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice.Infection and immunity · 2000Article
- Article
- Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells.Infection and immunity · 1999Article
- Production of interleukin-12 by murine macrophages in response to bacterial peptidoglycan.Infection and immunity · 1998Article
- Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis.Infection and immunity · 1998Article
- Interleukin-12 is critical for induction of nitric oxide-mediated immunosuppression following vaccination of mice with attenuated Salmonella typhimurium.Infection and immunity · 1997Article
- Interleukin-12 in infectious diseases.Clinical microbiology reviews · 1997Review
- Intranasal infection of beige mice with Mycobacterium avium complex: role of neutrophils and natural killer cells.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquired cellular resistance against Mycobacterium avium complex (MAC) infections involves the induction of Th1 type gamma interferon (IFN-gamma)-producing T cells. Interleukin-12 (IL-12) is a cytokine involved in the control of IFN-gamma production by T cells and NK cells. The role of IL-12 in the response to MAC infection was investigated. Depletion of endogenous IL-12 by injection of monoclonal antibody prior to and during intranasal infection with MAC resulted in an 150- to 550-fold increase in bacterial load in lung, spleen, and liver homogenates by 10 weeks postinfection. Depletion of IL-12 abrogated the ability of spleen cell cultures to produce IFN-gamma in response to stimulus with live MAC. IL-12-depleted mice showed a 75% decrease in the number of inflammatory cells entering the lungs following intranasal infection with MAC, with significant reductions in cytotoxic activity and nitric oxide production by lung cells. This work suggests that IL-12 plays a major role in the activation of IFN-gamma-producing cells during MAC infection.
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