ArticleInfection and immunity1995
Generation of interleukin-8 from human monocytes in response to Trichomonas vaginalis stimulation.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Cleavage/alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract.PloS one · 2015Trial
- Immunomodulatory Effects of the Antimicrobial Peptide KR-20: Implications for Trichomoniasis.Molecules (Basel, Switzerland) · 2026Article
- Hallmarks of Bacterial Vaginosis.Diagnostics (Basel, Switzerland) · 2025Review
- Altered Innate Immunity and Damaged Epithelial Integrity in Vaginal Microbial Dysbiosis.Frontiers in reproductive health · 2022Article
- Immune cell arrival kinetics to peritoneum and role during murine-experimental trichomoniasis.Parasitology · 2021Article
- Neutrophil interactions with the sexually transmitted parasiteOpen biology · 2020Review
- Association between Trichomonas vaginalis infection and cervical lesions: a population-based, nested case-control study in Taiwan.Parasitology research · 2020Article
- Paradigms of Protist/Bacteria Symbioses Affecting Human Health:Frontiers in microbiology · 2020Review
- The Role of Small Extracellular Vesicles in Viral-Protozoan Symbiosis: Lessons FromFrontiers in cellular and infection microbiology · 2020Article
- Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study.Parasites & vectors · 2019Article
- Trichomonas vaginalis: Pathogenesis, Symbiont Interactions, and Host Cell Immune Responses.Trends in parasitology · 2018Review
- Neutrophils kill the parasite Trichomonas vaginalis using trogocytosis.PLoS biology · 2018Article
- Adenosine reduces reactive oxygen species and interleukin-8 production by Trichomonas vaginalis-stimulated neutrophils.Purinergic signalling · 2017Article
- Leukocyte Lysis and Cytokine Induction by the Human Sexually Transmitted Parasite Trichomonas vaginalis.PLoS neglected tropical diseases · 2016Article
- Trichomoniasis immunity and the involvement of the purinergic signaling.Biomedical journal · 2016Review
- The Pathogenesis of Human Cervical Epithelium Cells Induced by Interacting with Trichomonas vaginalis.PloS one · 2015Article
- Superoxide anion production by human neutrophils activated by Trichomonas vaginalis.The Korean journal of parasitology · 2013Article
- IL-10 release by bovine epithelial cells cultured with Trichomonas vaginalis and Tritrichomonas foetus.Memorias do Instituto Oswaldo Cruz · 2013Article
- Involvement of purinergic signaling on nitric oxide production by neutrophils stimulated with Trichomonas vaginalis.Purinergic signalling · 2012Article
- Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are the predominant inflammatory cells found in the vaginal discharges of patients with Trichomonas vaginalis infection. We have investigated the possible role of interleukin-8 (IL-8) in the inflammatory response elicited by T. vaginalis infection. This study has shown that T. vaginalis induces blood monocytes to produce large amounts of bioactive IL-8, mainly by membrane components of T. vaginalis (MTV). Monocyte-derived IL-8 induced by MTV was dose and time dependent. The peak level of IL-8 was 102 +/- 11 ng/ml of conditioned media (mean +/- standard error; n = 5) obtained from MTV-stimulated monocytes (MTVCM) at 36 h of cultivation. With a multichamber chemotactic assay, we found an optimal neutrophil chemotaxis (177 +/- 14 migrated cells) induced by MTVCM collected at 16 h of cultivation when the level of IL-8 was 42 +/- 8 ng/ml. A neutralizing monoclonal antibody directed against IL-8, but not the irrelevant antibodies, significantly blocked the neutrophil chemotactic activity (decreased from 153 +/- 6 to 23 +/- 3 migrated cells; n = 3 [P < 0.001]) induced by MTVCM. Moreover, the maximum increase of the IL-8 mRNA level from MTV-treated monocytes was observed after a 5-h cultivation and decreased thereafter. Monocytes cocultured with MTV in the presence of a neutralizing monoclonal antibody directed against tumor necrosis factor alpha, but not against IL-1 beta, decreased IL-8 production by 25% (P < 0.05), indicating that the release of IL-8 in MTV-stimulated monocytes is partially dependent on tumor necrosis factor alpha. The capacity of MTV-induced monocytes to synthesize IL-8 suggests that these cells can contribute to the induction of the acute inflammatory response seen in T. vaginalis infection.
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