ArticleInfection and immunity1995
Relationship between virulence of Mycobacterium avium strains and induction of tumor necrosis factor alpha production in infected mice and in in vitro-cultured mouse macrophages.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Mycobacterium avium biofilm attenuates mononuclear phagocyte function by triggering hyperstimulation and apoptosis during early infection.Infection and immunity · 2014Article
- Virulence and immune response induced by Mycobacterium avium complex strains in a model of progressive pulmonary tuberculosis and subcutaneous infection in BALB/c mice.Infection and immunity · 2013Article
- Dynamics of immune effector mechanisms during infection with Mycobacterium avium in C57BL/6 mice.Immunology · 2013Article
- Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.PloS one · 2013Article
- Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection.Infection and immunity · 2007Article
- Pathogenesis of Mycobacterium avium infection: typical responses to an atypical mycobacterium?Immunologic research · 2006Review
- Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics.Infection and immunity · 2005Article
- Article
- Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium.Infection and immunity · 2002Article
- Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways.Infection and immunity · 2002Article
- Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice.Infection and immunity · 2002Article
- Article
- Effects of recombinant granulocyte-colony stimulating factor administration during Mycobacterium avium infection in mice.Clinical and experimental immunology · 2001Article
- Minor role played by type I tumour necrosis factor receptor in the control of Mycobacterium avium proliferation in infected mice.Immunology · 2000Article
- Article
- The virulence plasmid of Yersinia, an antihost genome.Microbiology and molecular biology reviews : MMBR · 1998Review
- Cytokine induction in murine macrophages infected with virulent and avirulent Rhodococcus equi.Infection and immunity · 1998Article
- Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection.Infection and immunity · 1998Article
- Production of tumor necrosis factor and nitric oxide by macrophages infected with live and dead mycobacteria and their suppression by an interleukin-10-secreting recombinant.Infection and immunity · 1997Article
- Evidence for a reduced chemokine response in the lungs of beige mice infected with Mycobacterium avium.Immunology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the ability of two Mycobacterium avium strains with different virulences to induce tumor necrosis factor alpha (TNF) synthesis by mouse resident peritoneal macrophages (RPM phi) in vitro in an experiment to look for a possible correlation between virulence and this TNF-inducing capacity. The low-virulence strain, 1983, induced significantly higher production of TNF by RPM phi than did the high-virulence strain, ATCC 25291. TNF neutralization during culture of infected RPM phi resulted in enhancement of growth of strain 1983 and had no effect on growth of strain ATCC 25291; TNF treatment of strain ATCC 25291-infected macrophages had no effect on mycobacterial growth. The extent of M. avium growth and the amount of TNF synthesis were independent of the presence of contaminating T cells or NK cells in the macrophage monolayers. Intraperitoneal administration of anti-TNF monoclonal antibodies to BALB/c mice infected intravenously with M. avium 1983 abrogated the elimination of the bacteria in the liver and caused a slight increase in bacterial growth in the spleen. Neutralization of TNF led to a minor increase in the proliferation of M. avium ATCC 25291 in the liver and spleen of BALB/c mice late in infection. Anti-TNF treatment did not affect the growth of the two M. avium strains in BALB/c.Bcgr (C.D2) mice, suggesting that restriction of M. avium strains to induce TNF production by macrophages may limit their ability to proliferate both in vitro and in vivo.
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