ArticleGut1995
Detection of low bone mineral density by dual energy x ray absorptiometry in unsuspected suboptimally treated coeliac disease.
Article in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- A Call for Research on the Prognostic Role of Follow-Up Histology in Celiac Disease: A Systematic Review.Frontiers in physiology · 2019Pooled it
- Guideline
- The Impact of Celiac Disease on Complication Rates After Total Joint Arthroplasty: A Matched Cohort Study.Arthroplasty today · 2022Article
- Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease.Journal of bone metabolism · 2018Review
- Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach.Nutrients · 2013Review
- Evaluation and management of skeletal health in celiac disease: position statement.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Review
- No evidence of circulating autoantibodies against osteoprotegerin in patients with celiac disease.World journal of gastroenterology · 2012Article
- Bone mineralization in celiac disease.Gastroenterology research and practice · 2012Article
- Role of Alendronate in Managing Osteoporosis in Celiac Disease - Illustrative Case Report.Gastroenterology research · 2011Article
- Positive celiac disease serology and reduced bone mineral density in adult women.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2010Article
- Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment.Sao Paulo medical journal = Revista paulista de medicina · 2009Article
- Bone in celiac disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Review
- Long-term fracture risk in patients with celiac disease: a population-based study in Olmsted County, Minnesota.Digestive diseases and sciences · 2008Article
- A case-control study of presentations in general practice before diagnosis of coeliac disease.The British journal of general practice : the journal of the Royal College of General Practitioners · 2007Article
- Dermatitis herpetiformis: no evidence of bone disease despite evidence of enteropathy.Digestive diseases and sciences · 2007Article
- Osteoporosis in children and adolescents: etiology and management.Paediatric drugs · 2005Review
- Calcium absorption and bone mineral density in celiacs after long term treatment with gluten-free diet and adequate calcium intake.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Article
- Article
- The clinical impact of metabolic bone disease in coeliac disease.Postgraduate medical journal · 2001Article
- Fortnightly review: coeliac disease.BMJ (Clinical research ed.) · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with coeliac disease may present with calcium malabsorption but it is unclear whether this results in longterm impairment of bone mineralisation. Dual energy x ray absorptiometry (DXA) was used to study bone mineral density in 34 asymptomatic coeliac disease patients, treated with a gluten free diet for at least two years, and also in 10 newly diagnosed or untreated patients. As expected, untreated patients had low bone mineral density in all regions. In the 29 treated female coeliac disease patients, overall mean values for age adjusted bone mineral density expressed as Z scores were normal although there were many patients with low values, particularly of the lumbar spine and total body. Scores in the postmenopausal patients were significantly worse than in the premenopausal patients and low mean Z scores were found in the five treated male patients. The subjects who had reduced bone mineral density could not be predicted clinically but, despite being asymptomatic, were more likely to have subtotal or partial villous atrophy on small intestinal biopsy (p < 0.0275). In conclusion, although many treated coeliac disease patients have normal bone mineral density, suboptimally treated and newly diagnosed or untreated patients have osteopenia. To reduce the risk of osteoporotic fractures, it is recommended that bone mineral density be measured in all treated coeliac disease patients and those with osteopenia have a repeat intestinal biopsy to assess disease activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.