ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1995
AIDS-related optic neuropathy: a histological, virological and ultrastructural study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Relapsing-remitting Optic Neuropathy in an HIV-infected Patient: Secondary Auto-immune Optic Neuropathy or Infectious Optic Neuropathy? A Case Report and Review of the Literature.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Bilateral optic neuritis from acute HIV infection.Neurology. Clinical practice · 2019Article
- Pattern- and motion-related visual evoked potentials in HIV-infected adults.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Infectious optic neuropathies: a clinical update.Eye and brain · 2015Review
- Ethambutol induced toxic optic neuropathy in HIV positive patients.International journal of ophthalmology · 2013Article
- Association between retinal nerve fiber layer thickness and abnormalities of vision in people with human immunodeficiency virus infection.American journal of ophthalmology · 2012Article
- Human immunodeficiency virus and its effects on the visual system.Infectious disease reports · 2012Review
- Vision function in HIV-infected individuals without retinitis: report of the Studies of Ocular Complications of AIDS Research Group.American journal of ophthalmology · 2008Article
- Human retinal microglia express candidate receptors for HIV-1 infection.The British journal of ophthalmology · 2005Article
- Neuro-ophthalmological disorders in HIV infected subjects with neurological manifestations.The British journal of ophthalmology · 2004Article
- Autonomic neuropathy in patients with HIV: course, impact of disease stage, and medication.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2000Article
- Vision recovery in human immunodeficiency virus-infected patients with optic neuropathy treated with highly active antiretroviral therapy: a case series.Indian journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundClinical and histopathological evidence of optic nerve axonal loss has been reported in AIDS patients without retinitis. The study was carried out to investigate the possible involvement of HIV-infected cells in the development of optic nerve degeneration.
methodsOptic nerves were obtained from eight AIDS patients and four normal controls. These nerves were morphologically and immunohistochemically analyzed. Additionally, using PCR amplification techniques, the retina and optic nerve samples obtained from three HIV-seropositive patients and one control were examined for the presence of HIV and cytomegalovirus antigens.
resultsWe noted various stages of axonal degeneration in the optic nerves obtained from AIDS patients in whom there was an absence of retinal findings. Characteristic glial changes involving hypertrophic astrocytes, vacuolated oligodendrocytes, and mononuclear phagocyte series cells were also seen in the AIDS optic nerves. HIV DNA was present in at least four of five optic nerves but in only one of five retinas. Control specimens were each negative for all cytomegalovirus and HIV antigens.
conclusionsDegeneration in the optic nerve may be mediated by HIV-infected macrophages rather than by direct viral infection of neurons. Axonal degeneration due to AIDS at the level of the optic nerve can occur independently of retinal infection.
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