ArticleDiabetologia1995
Role of syntaxin in mouse pancreatic beta cells.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 63 citations in OpenAlex.
- VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release.Cell structure and function · 2023Article
- Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection.International journal of molecular sciences · 2021Review
- Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice.Diabetes · 2012Article
- Pancreatic islet cells: a model for calcium-dependent peptide release.HFSP journal · 2010Article
- Correlation of syntaxin-1 and SNAP-25 clusters with docking and fusion of insulin granules analysed by total internal reflection fluorescence microscopy.Diabetologia · 2004Article
- Insulin granule dynamics in pancreatic beta cells.Diabetologia · 2003Review
- Nuclear KATP channels trigger nuclear Ca(2+) transients that modulate nuclear function.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion.The Biochemical journal · 1999Article
- Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.The EMBO journal · 1998Article
- Ca2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptor.The EMBO journal · 1998Article
- The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.The EMBO journal · 1997Article
- Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca(2+)- but not for guanosine 5'-[gamma-thio]triphosphate-induced secretion.The Biochemical journal · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional experiments demonstrate that anti-syntaxin antibodies inhibit CA(2+)-dependent insulin secretion in permeabilized islet cells. These data indicate that syntaxin 1 is present in the pancreatic beta cell and it is likely to play a functional role in the exocytosis of secretory granules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.