ArticleDiabetologia1995
Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 178 citations in OpenAlex.
- Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes.Diabetes · 2013Trial
- International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process.Diabetologia · 2026Article
- A Historical and Epistemological Review of Type 1 Diabetes Mellitus.Journal of clinical medicine · 2025Review
- Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative.Annals of the rheumatic diseases · 2019Article
- Observational
- Antibody fingerprints in lyme disease deciphered with high density peptide arrays.Engineering in life sciences · 2017Article
- The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.Annals of the New York Academy of Sciences · 2013Review
- Autoantibodies to harmonin and villin are diagnostic markers in children with IPEX syndrome.PloS one · 2013Article
- Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications.BMC immunology · 2011Article
- Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.Expert opinion on medical diagnostics · 2010Article
- Prediction of type 1 diabetes in the general population.Diabetes care · 2010Article
- Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories.Clinical trials (London, England) · 2010Article
- Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.Journal of autoimmunity · 2009Article
- Detection of GAD65 autoreactive T-cells by HLA class I tetramers in type 1 diabetic patients.Journal of biomedicine & biotechnology · 2009Article
- Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.Clinical immunology (Orlando, Fla.) · 2008Article
- Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2.Diabetologia · 2008Article
- Biomarkers for type 1 diabetes.International journal of clinical and experimental medicine · 2008Article
- Engineering and expression of the intracellular domain of insulinoma-associated tyrosine phosphatase (IA-2ic), a type 1 diabetes autoantigen, in plants.Transgenic research · 2007Article
- Disease-associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes.Clinical and experimental immunology · 2001Article
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Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of islet autoantigens offers the possibility that antibody tests other than islet cell antibodies may be used for assessing risk of insulin-dependent diabetes mellitus (IDDM). The aim of this study was to determine the combination of islet autoantibody markers that could identify most future cases of IDDM. Islet cell antibodies, antibodies to glutamic acid decarboxylase (GAD)65, 37,000/40,000 M(r) islet tryptic fragments, carboxypeptidase-H, and islet cell autoantigen (ICA)69 were measured in sera from 100 newly-diagnosed IDDM patients, 27 individuals prior to onset of IDDM, and 83 control subjects. Islet cell antibodies were detected in 88% of IDDM patients and 81% with pre-IDDM, GAD65 antibodies in 70% of IDDM patients and 89% with pre-IDDM, and antibodies to 37,000/40,000 M(r) islet tryptic fragments in 54% of IDDM patients and in 48% with pre-IDDM. The latter were found only in conjunction with islet cell antibodies and were more frequent in young onset cases. All 20 IDDM patients and the 3 pre-IDDM subjects who had islet cell antibodies without GAD65 antibodies had antibodies to 37,000/40,000 M(r) islet tryptic fragments, and all but one had disease onset before age 15 years. No sera strongly immunoprecipitated in vitro translated ICA69 or carboxypeptidase-H; 4% of patients had anti-ICA69 and 11% anti-carboxypeptidase-H levels above those of the control subjects. The findings suggest that none of the single antibody specificities are as sensitive as islet cell antibodies, but that a combination of GAD65 antibodies and antibodies to 37,000/40,000 M(r) islet tryptic fragments has the potential to identify more than 90% of future cases of IDDM.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.