ArticleThe EMBO journal1995
Calmodulin binding to Drosophila NinaC required for termination of phototransduction.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 85 citations in OpenAlex.
- Differential activation of rhodopsin triggers distinct endocytic trafficking and recycling in vivo via differential phosphorylation.PloS one · 2024Article
- Myosin light chains: Teaching old dogs new tricks.Bioarchitecture · 2014Review
- Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors.Journal of neurophysiology · 2013Article
- Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- PDA (prolonged depolarizing afterpotential)-defective mutants: the story of nina's and ina's--pinta and santa maria, too.Journal of neurogenetics · 2012Review
- Protein Gq modulates termination of phototransduction and prevents retinal degeneration.The Journal of biological chemistry · 2012Article
- Dopaminergic modulation of ganglion-cell photoreceptors in rat.The European journal of neuroscience · 2012Article
- Characteristics of light chains of Chara myosin revealed by immunological investigation.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Article
- Characterization of novel calmodulin binding domains within IQ motifs of IQGAP1.Molecules and cells · 2011Article
- Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Why Drosophila to study phototransduction?Journal of neurogenetics · 2010Article
- Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.Experimental eye research · 2009Article
- Article
- Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- Genome-wide microarray analysis of TGFbeta signaling in the Drosophila brain.BMC developmental biology · 2004Article
- Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B).The Biochemical journal · 2001Article
- Modulation of the light response by cAMP in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Does Ca2+ reach millimolar concentrations after single photon absorption in Drosophila photoreceptor microvilli?Biophysical journal · 1999Article
- The ordered visual transduction complex of the squid photoreceptor membrane.Molecular neurobiology · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The ninaC locus encodes two unconventional myosins, p132 and p174, consisting of fused protein kinase and myosin head domains expressed in Drosophila photoreceptor cells. NinaC are the major calmodulin-binding proteins in the retina and the NinaC-calmodulin interaction is required for the normal subcellular localization of calmodulin as well as for normal photo-transduction. In the current report, we present evidence for two calmodulin-binding sites in NinaC, C1 and C2, which have different in vitro binding properties. C1 was found to be common to both p132 and p174 while C2 was unique to p174. To address the requirements for calmodulin binding at each site in vivo, we generated transgenic flies expressing ninaC genes deleted for either C1 or C2. We found that the spatial localization of calmodulin depended on binding to both C1 and C2. Furthermore, mutation of either site resulted in a defective photoresponse. A prolonged depolarization afterpotential (PDA) was elicited at lower light intensities than necessary to produce a PDA in wild-type flies. These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.