ReviewEnvironmental health perspectives1995
Possible mechanisms of action of environmental contaminants on St. Lawrence beluga whales (Delphinapterus leucas).
Review in Environmental health perspectives, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 209 citations in OpenAlex.
- Marine mammals as indicators of Anthropocene Ocean Health.npj biodiversity · 2024Review
- Chromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (delphinus delphis).BMC genomics · 2024Article
- Navigating the unknown: assessing anthropogenic threats to beaked whales, family Ziphiidae.Royal Society open science · 2024Article
- Influence of Life-History Parameters on Persistent Organic Pollutant Concentrations in Blubber of Eastern North Pacific Gray Whales (Environmental science & technology · 2022Article
- Ecological Risks Due to Immunotoxicological Effects on Aquatic Organisms.International journal of molecular sciences · 2021Review
- Using energy budgets to combine ecology and toxicology in a mammalian sentinel species.Scientific reports · 2017Article
- Integrative behavioral ecotoxicology: bringing together fields to establish new insight to behavioral ecology, toxicology, and conservation.Current zoology · 2017Article
- Trace Element Concentrations in Liver of 16 Species of Cetaceans Stranded on Pacific Islands from 1997 through 2013.Archives of environmental contamination and toxicology · 2016Article
- Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies.Environmental health perspectives · 2011Article
- Article
- Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse.Aquatic toxicology (Amsterdam, Netherlands) · 2010Article
- Wildlife cancer: a conservation perspective.Nature reviews. Cancer · 2009Review
- The risk of infection from polychlorinated biphenyl exposure in the harbor porpoise (Phocoena phocoena): a case-control approach.Environmental health perspectives · 2006Article
- Individual-based model framework to assess population consequences of polychlorinated biphenyl exposure in bottlenose dolphins.Environmental health perspectives · 2006Article
- Contamination and biomarkers in the great blue heron, an indicator of the state of the st. Lawrence river.Ecotoxicology (London, England) · 2006Article
- Wildlife as sentinels of human health effects in the Great Lakes--St. Lawrence basin.Environmental health perspectives · 2001Article
- Effects of dibutyl phthalate as an environmental endocrine disruptor on gonadal sex differentiation of genetic males of the frog Rana rugosa.Environmental health perspectives · 2000Article
- Environmental endocrine disruption: an effects assessment and analysis.Environmental health perspectives · 1998Review
- Chronic toxicity of environmental contaminants: sentinels and biomarkers.Environmental health perspectives · 1997Review
- Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.Environmental health perspectives · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A small isolated population of beluga whales (Delphinapterus leucas) that are highly contaminated by pollutants, mostly of industrial origin, resides in the St. Lawrence estuary, Québec, Canada. Overhunting in the first half of the century was the probable cause for this population to dwindle from several thousand animals to the current estimate of 500. The failure of the population to recover might be due to contamination by organochlorine compounds, which are known to lead to reproductive failure and immunosuppression in domestic and laboratory animals and seals. Functional and morphological changes have been demonstrated in thyroid gland and adrenal cortex in many species exposed to organochlorinated compounds, including seals. Morphological lesions, although different, were also found in belugas. Functional evaluation of thyroid and adrenal glands of contaminated (St. Lawrence) versus much less contaminated (Arctic) belugas is currently under way. Necropsy of St. Lawrence belugas showed numerous severe and disseminated infections with rather mildly pathogenic bacteria, which suggests immunosuppression. Organochlorine compounds and other contaminants found in beluga whales cause immunosuppression in a variety of animal species including seals. Thirty-seven percent of all the tumors reported in cetaceans were observed in St. Lawrence beluga whales. This could be explained by two different mechanisms: high exposure to environmental carcinogens and suppression of immunosurveillance against tumors. Overall, St. Lawrence belugas might well represent the risk associated with long-term exposure to pollutants present in their environment and might be a good model to predict health problems that could emerge in highly exposed human populations over time.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.