ArticleVirchows Archiv : an international journal of pathology1995
Immunohistochemical and molecular analysis of p53, MDM2, proliferating cell nuclear antigen and Ki67 in benign and malignant peripheral nerve sheath tumours.
Article in Virchows Archiv : an international journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 133 citations in OpenAlex.
- From benign neurofibromas to malignant peripheral nerve sheath tumors (MPNST): a gaming among multiple factors.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Peripheral nerve sheath tumors in the head and neck in patients with APC gene deletion mutations: a case report and scoping review of the literature.Clinical and experimental pediatrics · 2025Article
- Cell culture in salivary gland tumor research: molecular insights of pathogenic targets and personalized medicine.Cytotechnology · 2025Review
- Robot-assisted minimally invasive bronchial resection with primary anastomosis for schwannoma arising from left main bronchus: a case report.Translational lung cancer research · 2024Article
- Surgical removal of an unusual huge solitary fibrous tumor in the mediastinum: a case report.Journal of cardiothoracic surgery · 2023Article
- Primary Cardiac Schwannoma: A Meta-Analysis of Individual Case Reports.Journal of clinical medicine · 2023Review
- Schwannoma arising in mediastinal lymph node diagnosed by endobronchial ultrasound.Respirology case reports · 2019Article
- Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor.Journal of cancer research and clinical oncology · 2018Article
- Article
- Malignant Peripheral Nerve Sheath Tumour of Small Intestine Presenting as Ileo-Ileal Intussusception - A Rare Tumour with Unusual Complication.Journal of clinical and diagnostic research : JCDR · 2015Article
- Malignant epithelioid schwannoma of the oral cavity in a cat.The Journal of veterinary medical science · 2014Article
- A case report of intrapulmonary schwannoma.General thoracic and cardiovascular surgery · 2014Article
- Clinical and molecular prognostic predictors of malignant peripheral nerve sheath tumor.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014Article
- Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma.BMJ case reports · 2013Article
- Malignant peripheral nerve sheath tumor of the small bowel: an unusual presentation with fatal outcome.Case reports in oncological medicine · 2013Article
- Malignant peripheral nerve sheath tumors: clinicopathological aspects, expression of p53 and survival.Clinics (Sao Paulo, Brazil) · 2012Article
- Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems.Acta neuropathologica · 2012Review
- [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition].Der Pathologe · 2010Article
- Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors.Neuro-oncology · 2009Article
- Biomaterial-induced sarcomagenesis is not associated with microsatellite instability.Virchows Archiv : an international journal of pathology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of 26 malignant peripheral nerve sheath tumours (MPNST) and 24 benign peripheral nerve sheath tumours (BPNST) were analysed immunocytochemically for p53 expression and the cell proliferation markers proliferating cell nuclear antigen (PCNA) and Ki67 (with MIB1). In 23/26 MPNST, 5%-65% of the tumour cell nuclei were immunoreactive for Ki67 with MIB1 while none of the 24 BPNST had nuclear staining exceeding 5%. Greater than 50% nuclear PCNA staining was detected in 25/26 MPNST compared with 8/24 BPNST; 17/26 MPNST showed 5-100% nuclear staining for p53 (13/26 > 20%), whereas none of the BPNST had nuclear staining exceeding 1%. The Ki67, PCNA and p53 immunostaining results correlated significantly with benign versus malignant (P < 0.001, P < 0.001 and P < 0.005, respectively) as well as mitotic rate (P < 0.001, P < 0.05 and P < 0.05). Ki67 immunostaining results correlated significantly with PCNA and p53, as did p53 and Ki67 and PCNA (P < 0.001 in both). Stepwise (logistic regression forward) multivariate analysis of the variable, benign versus malignant, revealed the strongest correlations with PCNA (P = 0.007) and Ki67 (P = 0.021). Direct confirmation of the presence of p53 protein was obtained by western blot analysis of 3 MPNST and 5 BPNST. Two MPNST, showing 90% and 30% immunoreactivity, were positive for p53, while one MPNST with 5% immunoreactivity and all 5 BPNST were negative. Southern blot analysis performed on the two MPNST with high p53 protein levels revealed no amplification of the MDM2 gene, suggesting that high p53 levels in MPNST are likely to be due to mutation. The results also indicate that PCNA and Ki67 are potentially useful in distinguishing BPNST from MPNST, particularly in problematic cases of cellular schwannoma versus MPNST. The detection of p53 in a large percentage of cells of a plexiform neurofibroma giving rise to MPNST and Ki67 in 5% and 25% of cells of two similar cases suggests that malignant transformation may be detected in some cases by p53 and proliferation markers prior to overt histological evidence of malignancy.
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