ArticleThe British journal of ophthalmology1995
Immunohistochemical evidence of neuronal and glial differentiation in retinoblastoma.
Article in The British journal of ophthalmology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 34 citations in OpenAlex.
- Tumor Environment of Retinoblastoma, Intraocular Cancer.Advances in experimental medicine and biology · 2020Article
- Immunohistochemical assay for neuron-specific enolase, synaptophysin, and RB-associated protein as a diagnostic aid in advanced retinoblastomas.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Retinoblastoma and retinal astrocytoma: unusual double tumour in one eye.The British journal of ophthalmology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study sought to investigate the histogenesis of retinoblastoma.
methodsOne hundred specimens of retinoblastomas were examined along with those of 18 astrocytic gliomas and 15 medulloblastomas to compare similarities of glial differentiation in retinoblastoma and the two types of brain tumour. Employing avidin-biotin immunoperoxidase technique, antibodies were applied against neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein (S-100).
resultsMost rosettes and fleurettes, and some undifferentiated cells in retinoblastomas were NSE positive, but GFAP and S-100 negative. GFAP and S-100 positive cells in retinoblastomas were detected mostly in well differentiated glial cells which were interpreted as reactive or non-neoplastic cells. Some of the GFAP and S-100 positive cells in retinoblastomas were defined as tumour cells that resembled neoplastic astrocytes in astrocytic gliomas and medulloblastomas.
conclusionRetinoblastoma may arise from primitive bipotential or multipotential cells capable of neuronal and glial differentiation.
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