ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]1995
Post-capillary venules in the "milky spots" of the greater omentum are the major site of plasma protein and leukocyte extravasation in rodent models of peritonitis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Tissue adhesion after surgical interventions (Review).Experimental and therapeutic medicine · 2025Review
- Conditions that promote transcellular neutrophil migration in vivo.Scientific reports · 2024Article
- Specialized immune responses in the peritoneal cavity and omentum.Journal of leukocyte biology · 2021Review
- Article
- The Greater Omentum-A Vibrant and Enigmatic Immunologic Organ Involved in Injury and Infection Resolution.Shock (Augusta, Ga.) · 2020Review
- Snapshot Study on the Value of Omentoplasty in Abdominoperineal Resection with Primary Perineal Closure for Rectal Cancer.Annals of surgical oncology · 2018Article
- The greater omentum as a site for pancreatic islet transplantation.CellR4-- repair, replacement, regeneration, & reprogramming · 2017Article
- Omental flap after pelvic exenteration for pelvic cancer.Surgery today · 2016Article
- Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.Nature communications · 2016Article
- Very-low and low-density lipoproteins induce neutral lipid accumulation and impair migration in monocyte subsets.Scientific reports · 2016Article
- Generation of a dual-functioning antitumor immune response in the peritoneal cavity.The American journal of pathology · 2013Article
- Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues.Tissue barriers · 2013Article
- Mesenchymal stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer therapy model.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- The omentum: anatomical, metabolic, and surgical aspects.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Review
- Perineal wound complications after abdominoperineal resection.Clinics in colon and rectal surgery · 2008Article
- The omentum.World journal of gastroenterology · 2000Article
- Mycoplasmal lipopeptide MALP-2 induces the chemoattractant proteins macrophage inflammatory protein 1alpha (MIP-1alpha), monocyte chemoattractant protein 1, and MIP-2 and promotes leukocyte infiltration in mice.Infection and immunity · 1999Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Intraperitoneal injection of inflammatory agents in the mouse and rat causes plasma protein and leukocyte extravasation into the peritoneal cavity. Following an intraperitoneal injection of zymosan A, the milky spots of the omentum were the only abdominal sites detected where intravenously administered Monastral Blue labeled interendothelial cell gaps responsible for plasma extravasation. In addition, when colored microspheres were intraventricularly administered to quantify blood flow, the omentum was the only abdominal organ which showed an increase in blood flow during zymosan A peritonitis. A combination of light and electron microscopy, plus measurement of myeloperoxidase activity (a marker of neutrophil accumulation) demonstrated that the omental milky spots are the major route through which leukocytes migrate into the peritoneal cavity. Identical structures in the pleura likewise are the sites of protein leakage into the pleural cavity. In contrast, selective sites of protein and cellular extravasation could not be detected in the synovial lining of the inflamed knee joint.
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