ArticlePflugers Archiv : European journal of physiology1995
Multiple calcium channel subtypes in isolated rat chromaffin cells.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 78 citations in OpenAlex.
- A subfraction obtained from the venom of the tarantulaToxicon: X · 2023Article
- Specificity in the interaction of high-voltage-activated CaJournal of neurophysiology · 2018Article
- L-type calcium channels in exocytosis and endocytosis of chromaffin cells.Pflugers Archiv : European journal of physiology · 2018Review
- Article
- Regulation by L-type calcium channels of endocytosis: an overview.Journal of molecular neuroscience : MN · 2012Review
- Comparison of Ca2+ currents of chromaffin cells from normotensive Wistar Kyoto and spontaneously hypertensive rats.Cellular and molecular neurobiology · 2010Article
- The quantal secretion of catecholamines is impaired by the accumulation of beta-adrenoceptor antagonists into chromaffin cell vesicles.British journal of pharmacology · 2010Article
- Pharmacological and biophysical properties of Ca2+ channels and subtype distributions in human adrenal chromaffin cells.Pflugers Archiv : European journal of physiology · 2008Article
- T-type channels-secretion coupling: evidence for a fast low-threshold exocytosis.Pflugers Archiv : European journal of physiology · 2006Review
- Exposure to cAMP and beta-adrenergic stimulation recruits Ca(V)3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins.The Journal of physiology · 2004Article
- Modeling of stimulation-secretion coupling in a chromaffin cell.Pflugers Archiv : European journal of physiology · 2004Article
- Voltage-activated Ca(2+) channels and their role in the endocrine function of the pituitary gland in newborn and adult mice.The Journal of physiology · 2004Article
- Distinct potentiation of L-type currents and secretion by cAMP in rat chromaffin cells.Biophysical journal · 2003Article
- Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- R-Type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Role of calcium channels in catecholamine secretion in the rat adrenal gland.The Journal of physiology · 1999Article
- Expression and subunit interaction of voltage-dependent Ca2+ channels in PC12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Re-evaluation of the P/Q Ca2+ channel components of Ba2+ currents in bovine chromaffin cells superfused with solutions containing low and high Ba2+ concentrations.Pflugers Archiv : European journal of physiology · 1996Article
- Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB.British journal of pharmacology · 1996Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By using the whole-cell configuration of the patch-clamp technique we have investigated the pharmacological properties of Ca2+ channels in short-term cultured rat chromaffin cells. In cells held at a membrane potential of --80 mV, using 10 mM Ba2+ as the charge carrier, only high-voltage-activated (HVA) Ca2+ channels were found. Ba2+ currents (IBa) showed variable sensitivity to dihydropyridine (DHP) Ca2+ channel agonists and antagonists. Furnidipine, a novel DHP antagonist, reversibly blocked the current amplitude by 22% and 48%, at 1 microM and 10 microM respectively, during short (15-50 ms) depolarizing pulses to 0 mV. The L-type Ca2+ channel agonist Bay K 8644 (1 microM) caused a variable potentiation of HVA currents that could be better appreciated at low rather than at high depolarizing steps. Increase of IBa was accompanied by a 20-mV shift in the activation curves for Ca2+ channels towards more hyperpolarizing potentials. Application of the conus toxin omega-conotoxin GVIA (GVIA; 1 microM) blocked 31% of IBa; blockade was irreversible upon removal of the toxin from the extracellular medium. omega-Agatoxin IVA (IVA; 100 nM) produced a 15% blockade of IBa. omega-Conotoxin MVIIC (MVIIC; 5 microM) produced a 36% blockade of IBa; such blockade seems to be related to both GVIA-sensitive (N-type) and GVIA-resistant Ca2+ channels. The sequential addition of supramaximal concentrations of furnidipine (10 microM), GVIA (1 microM), IVA (100 nM) and MVIIC (3 microM) produced partial inhibition of IBa, which were additive. Our data suggest that the whole cell IBa in rat chromaffin cells exhibits at least four components.(ABSTRACT TRUNCATED AT 250 WORDS)
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