ArticleThe Journal of clinical investigation1995
Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 164 citations in OpenAlex.
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- Idiopathic pulmonary fibrosis predicts local recurrence following surgery in patients with non-small cell lung cancer.Journal of cancer research and clinical oncology · 2026Article
- A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.JCI insight · 2026Article
- Interstitial pneumonia microenvironment promotes metastasis to the mediastinal lymph nodes and lungs.Frontiers in oncology · 2025Article
- Molecular signatures of alveolar type II cell differentiation in acute respiratory distress syndrome.Frontiers in medicine · 2025Article
- HER2 drives lung fibrosis by activating a metastatic cancer signature in invasive lung fibroblasts.The Journal of experimental medicine · 2022Article
- Fibrinogen mediates cadmium-induced macrophage activation and serves as a predictor of cadmium exposure in chronic obstructive pulmonary disease.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- RNA Sequencing of Epithelial Cell/Fibroblastic Foci Sandwich in Idiopathic Pulmonary Fibrosis: New Insights on the Signaling Pathway.International journal of molecular sciences · 2022Article
- Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis.The American journal of pathology · 2021Article
- Venous Thromboembolic Disease in Chronic Inflammatory Lung Diseases: Knowns and Unknowns.Journal of clinical medicine · 2021Review
- Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2021Article
- Vascular permeability in the fibrotic lung.The European respiratory journal · 2020Article
- Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2019Review
- Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice.Blood advances · 2018Article
- Upregulation of P2YFrontiers in cellular and infection microbiology · 2018Article
- Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes.Experimental lung research · 2017Article
- Article
- Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury.Clinical and translational medicine · 2015Article
- Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis.Redox biology · 2015Review
- Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor.American journal of respiratory cell and molecular biology · 2015Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Bleomycin-induced lung injury is an established murine model of human pulmonary fibrosis. Although procoagulant molecules (e.g., tissue factor [TF]) and fibrinolytic components (e.g., urokinase [u-PA] and type 1 plasminogen activator inhibitor [PAI-1]) have been detected in alveolar fluid from injured lungs, the origin of these molecules remains unknown. We therefore examined the expression of procoagulant and fibrinolytic components in relation to the distribution of parenchymal fibrin in bleomycin-injured lungs. Extravascular fibrin localized to the alveolar and extracellular matrix in injured lung tissue. Injured lung tissue extracts contained elevated levels of PAI-1 activity and decreased levels of u-PA activity. Whole lung PAI-1 and TF mRNAs were dramatically induced by lung injury. In situ hybridization of injured lungs revealed that PAI-1, u-PA, and TF mRNAs were induced within the fibrin-rich fibroproliferative lesions, primarily in fibroblast-like and macrophagelike cells, respectively, while TF mRNA was also induced in perilesional alveolar cells. Taken together, these observations suggest that the induction of PAI-1 and TF gene expression plays and important role in the formation and persistence of extracellular fibrin in bleomycin injured murine lungs.
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Registered trials
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