ArticleMolecular and cellular biology1995
Functional regions of the mouse interleukin-10 receptor cytoplasmic domain.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 107 citations in OpenAlex.
- IL-22, a vital cytokine in autoimmune diseases.Clinical and experimental immunology · 2024Review
- IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic.Frontiers in immunology · 2022Review
- The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm.Frontiers in immunology · 2022Review
- Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses.Science immunology · 2021Article
- Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces.Frontiers in immunology · 2020Review
- Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain.PloS one · 2017Article
- IL-10: A Multifunctional Cytokine in Viral Infections.Journal of immunology research · 2017Review
- The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Current topics in microbiology and immunology · 2014Review
- Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties.The Journal of biological chemistry · 2012Article
- The Hyper-IgE Syndromes: Lessons in Nature, From Bench to Bedside.The World Allergy Organization journal · 2012Article
- IL-10R1 S138G loss-of-function polymorphism is associated with extrapulmonary tuberculosis risk development in Tunisia.Molecular biology reports · 2012Article
- Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase.PloS one · 2011Article
- Polymorphisms in the gene encoding bovine interleukin-10 receptor alpha are associated with Mycobacterium avium ssp. paratuberculosis infection status.BMC genetics · 2010Article
- SNPs in the bovine IL-10 receptor are associated with somatic cell score in Canadian dairy bulls.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- SNP-SNP interactions in breast cancer susceptibility.BMC cancer · 2006Article
- Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype.Immunogenetics · 2005Article
- Review
- Induction of specific T-cell responses, opsonizing antibodies, and protection against Plasmodium chabaudi adami infection in mice vaccinated with genomic expression libraries expressed in targeted and secretory DNA vectors.Infection and immunity · 2003Article
- Cell cycle effects of IL-10 on malignant B-1 cells.Genes and immunity · 2001Article
- Mechanisms of interleukin-10-mediated immune suppression.Immunology · 2001Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functions of wild-type and mutant mouse interleukin-10 receptors (mIL-10R) expressed in murine Ba/F3 cells were studied. As observed previously, IL-10 stimulates proliferation of IL-10R-expressing Ba/F3 cells. Accumulation of viable cells in the proliferation assay is to a significant extent balanced by concomitant cell death. Moreover, growth in IL-10 also induces a previously unrecognized response, differentiation of the cells, as evidenced both by formation of large clusters of cells in cultures with IL-10 and by induction or enhancement of expression of several cell surface antigens, including CD32/16, CD2, LECAM-1 (v-selectin), and heat-stable antigen. Two distinct functional regions near the C terminus of the mIL-10R cytoplasmic domain which mediate proliferation were identified; one of these regions also mediates the differentiation response. A third region proximal to the transmembrane domain was identified; removal of this region renders the cell 10- to 100-fold more sensitive to IL-10 in the proliferation assay. In cells expressing both wild-type and mutant IL-10R, stimulation with IL-10 leads to tyrosine phosphorylation of the kinases JAK1 and TYK2 but not JAK2 or JAK3 under the conditions tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.