ArticleProceedings of the National Academy of Sciences of the United States of America1995
Olfactory transduction is intrinsically noisy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Shedding light on human olfaction: Electrophysiological recordings from sensory neurons in acute slices of olfactory epithelium.iScience · 2023Article
- Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures.eLife · 2018Article
- The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons.The Journal of general physiology · 2016Article
- Spontaneously active NaV1.5 sodium channels may underlie odor sensitivity.Journal of neurophysiology · 2016Article
- Receptor arrays optimized for natural odor statistics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Normalized Neural Representations of Complex Odors.PloS one · 2016Article
- Stable odor recognition by a neuro-adaptive electronic nose.Scientific reports · 2015Article
- NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.Journal of neurophysiology · 2014Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Primary culture of embryonic rat olfactory receptor neurons.In vitro cellular & developmental biology. Animal · 2012Article
- Visual threshold is set by linear and nonlinear mechanisms in the retina that mitigate noise: how neural circuits in the retina improve the signal-to-noise ratio of the single-photon response.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Origin of basal activity in mammalian olfactory receptor neurons.The Journal of general physiology · 2010Article
- An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia.The American journal of psychiatry · 2009Article
- Altered olfactory epithelial structure and function in feline models of mucopolysaccharidoses I and VI.The Journal of comparative neurology · 2008Article
- Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The sense of smell, its signalling pathways, and the dichotomy of cilia and microvilli in olfactory sensory cells.BMC neuroscience · 2007Review
- CNS*2007. Abstracts of the 16th Annual Computational Neuroscience Meeting, Toronto, Canada, 7-12 July 2007.BMC neuroscience · 2007Article
- Elementary response of olfactory receptor neurons to odorants.Science (New York, N.Y.) · 2005Article
- Responses to prolonged odour stimulation in frog olfactory receptor cells.The Journal of physiology · 2001Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sources of noise that limit olfactory signal detection were investigated in dissociated rat olfactory receptor cells. Near-threshold odorant-evoked currents exhibited large random fluctuation. However, similar fluctuations were observed in the absence of applied odorants when currents were induced by elevating the intracellular cyclic AMP concentration. This suggests that the fluctuations reflect noise intrinsic to the transduction mechanism, rather than the quantal nature of an odorant stimulus. For many odorants, this intrinsic noise may preclude the reliable detection of single odorant molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.