ArticleMolecular biology of the cell1995
Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
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- The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature.Physiological genomics · 2021Article
- αvβ8 integrin adhesion and signaling pathways in development, physiology and disease.Journal of cell science · 2020Review
- A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids.Cancers · 2020Article
- A Novel Laminin-Binding Protein Mediates Microbial-Endothelial Cell Interactions and Facilitates Dissemination of Lyme Disease Pathogens.The Journal of infectious diseases · 2020Article
- Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.The American journal of pathology · 2019Article
- Integrins promote axonal regeneration after injury of the nervous system.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression.Oncogene · 2017Article
- The role of pericytic laminin in blood brain barrier integrity maintenance.Scientific reports · 2016Article
- Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin.The Journal of biological chemistry · 2016Article
- Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish.PLoS genetics · 2015Article
- Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention.Circulation · 2015Article
- Role of integrin subunits in mesenchymal stem cell differentiation and osteoblast maturation on graphitic carbon-coated microstructured surfaces.Biomaterials · 2015Article
- Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair.American journal of physiology. Renal physiology · 2014Article
- Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation.Journal of oncology · 2012Article
- The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.Development (Cambridge, England) · 2011Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Cell adhesion and signaling networks in brain neurovascular units.Current opinion in hematology · 2009Review
- Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation.The Journal of biological chemistry · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Integrins are major receptors used by cells to interact with extracellular matrices. In this paper, we identify the first ligands for the beta 8 family of integrins, presenting evidence that integrin heterodimers containing the beta 8 subunit mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin. A polyclonal antibody, anti-beta 8-Ex, was prepared to a bacterial fusion protein expressing an extracellular portion of the chicken beta 8 subunit. In nonreducing conditions, this antibody immunoprecipitated from surface-labeled embryonic dorsal root ganglia neurons a M(r) 100 k protein, the expected M(r) of the beta 8 subunit, and putative alpha subunit(s) of M(r) 120 k. Affinity-purified anti-beta 8-Ex strongly inhibited sensory neurite outgrowth on laminin-1, collagen IV, and fibronectin-coated substrata. Binding sites were identified in a heat-resistant domain in laminin-1 and in the carboxyl terminal, 40-kDa fibronectin fragment. On substrates coated with the carboxyl terminal fragment of fibronectin, antibodies to beta 1 and beta 8 were only partially effective alone, but were completely effective in combination, at inhibiting neurite outgrowth. Results thus indicate that the integrin beta 8 subunit in association with one or more alpha subunits forms an important set of extracellular matrix receptors on sensory neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.