ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1995
Expression and in vitro function of beta 1-integrin laminin receptors in the developing avian ciliary ganglion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Integrin ligands block mechanical signal transduction in baroreceptors.Life science alliance · 2023Article
- Article
- β1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival.PloS one · 2012Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Studies on integrins in the nervous system.Methods in enzymology · 2007Review
- Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Impaired axonal regeneration in alpha7 integrin-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Embryonic neurons adapt to the inhibitory proteoglycan aggrecan by increasing integrin expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.The Journal of cell biology · 1997Article
- An antibody to the tetraspan membrane protein CD9 promotes neurite formation in a partially alpha3beta1 integrin-dependent manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Native chick laminin-4 containing the beta 2 chain (s-laminin) promotes motor axon growth.The Journal of cell biology · 1996Article
- Role of laminin and integrin interactions in growth cone guidance.Molecular neurobiology · 1996Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In chick development, ciliary ganglion (CG) neurons go through a period of axon extension from approximately embryonic day (E)4 to E8, followed by a period of synaptogenesis and neuronal cell death. By examining the immunohistochemical localization of laminin, in conjunction with Dil labeling of the ciliary nerve projection, we have determined that the pathway taken by these neurons is rich in laminin expression. Therefore, laminins are good candidate molecules for mediating outgrowth of these neurons in vivo. In vitro, the ability of CG neurons to extend neurites on laminin-1 (EHS laminin, alpha 1 beta 1 gamma 1) is maximal up to E8, then declines dramatically. CG neuron outgrowth on laminin-1 requires the activity of beta 1-class integrins. We have used subunit-specific antibodies to determine which of the five beta 1-containing heterodimers known to be laminin receptors (alpha 1 beta 1, alpha 2 beta 1, alpha 6 beta 1, alpha 7 beta 1) are expressed, and which mediate neurite outgrowth. While we could not detect expression of alpha 2 or alpha 7, we have found that alpha 1, alpha 3 beta 1, and alpha 6 beta 1 are expressed on the surface of ciliary ganglion neuron cell bodies and axons, both in vitro and in vivo. Furthermore, antibodies against alpha 3 and alpha 6, but not alpha 1, interfered with CG neurite outgrowth on laminin-1 in vitro. Taken together, these data suggest that interactions of cell surface alpha 3 beta 1 and alpha 6 beta 1 integrins with laminin-1 are likely to mediate growth of CG neurons during pathfinding in vivo.
Indexed as
Identifiers
7542700PMC2712128W1928244427What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.