ArticleInternational journal of pancreatology : official journal of the International Association of Pancreatology1995
The effect of platelet activating factor antagonist (BN 52021) on acute experimental pancreatitis with reference to multiorgan oxidative stress.
Article in International journal of pancreatology : official journal of the International Association of Pancreatology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Role of platelet-activating factor in the pathogenesis of acute pancreatitis.World journal of gastroenterology · 2006Review
- The role of the intestine in the pathophysiology and management of severe acute pancreatitis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2003Article
- Differential oxidative injury in extrapancreatic tissues during experimental pancreatitis: modification of lung proteins by 4-hydroxynonenal.Digestive diseases and sciences · 2001Article
- Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells.The American journal of pathology · 1999Article
- Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis.Inflammation · 1998Article
- Article
- Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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3 authors at 1 institution in 1 country.
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Abstract
Acute hemorrhagic pancreatitis was induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate. Rats were treated with platelet-activating factor receptor (PAF) antagonist--BN 52021 (5 mg/kg) and sacrificed at 1 and 3 h after induction of acute pancreatitis. Malondialdehyde and sulfhydryl groups concentration were measured in pancreatic, lung, and liver tissue as a parameter of oxidant-antioxidant balance. We have shown that BN 52021 exerts only partial protecting effect against Na-TC-induced AP in rats. The positive effects of BN 52021 were expressed by: (1) Significant reduction of hyperamylasemia accompanied by lower malondialdehyde accumulation in pancreatic tissue; (2) Prevention of sulflhydryl groups depletion in lung tissue; (3) Diminution of necrotic and inflammatory changes in pancreatic tissue; and (4) Improvement of survival rate. We suggest that these effects may depend on the inhibition of PAF-mediated activation and oxidant generation by phagocytes.
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