ArticleBiophysical journal1995
Single channel behavior of recombinant beta 2 gap junction connexons reconstituted into planar lipid bilayers.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs.Structure (London, England : 1993) · 2021Article
- Electrical coupling and its channels.The Journal of general physiology · 2018Review
- Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells.The Journal of biological chemistry · 2014Article
- Functional analysis and regulation of purified connexin hemichannels.Frontiers in physiology · 2014Review
- The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes.Journal of structural biology · 2009Article
- Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density.Cell communication & adhesion · 2008Article
- Connexins/connexons. Cell-free expression.Methods in molecular biology (Clifton, N.J.) · 2001Article
- Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation.The Journal of cell biology · 2000Article
- Multiple connexin proteins in single intercellular channels: connexin compatibility and functional consequences.Journal of bioenergetics and biomembranes · 1996Review
- Connexin expression systems: to what extent do they reflect the situation in the animal?Journal of bioenergetics and biomembranes · 1996Review
- Heteromeric connexons in lens gap junction channels.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The beta 2 gap junction protein (Cx26) was expressed in an insect cell line by infection with a baculovirus vector containing the rat beta 2 cDNA. Isolated beta 2 gap junction connexons were reconstituted into planar lipid bilayers. Single channel activity was observed with a unitary conductance of 35-45 pS in 200 mM KCl. Channels with conductance values of 60 pS and 90-110 pS also coexisted with the lower conducting channel suggesting that there are channels with different conductance properties within a population of connexons. Channel activity was observed at voltages of up to 150 mV. Furthermore, the characterization of these channel properties from the beta 2 connexons that were generated by this heterologous expression system has provided the basis for identifying an endogenous beta 2 connexon channel in material reconstituted from native rat liver gap junctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.