ArticleNeuron1995
The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.
Article in Neuron, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.PLoS genetics · 2012Pooled it
- The extracellular matrix as a dynamic regulator of brain function and plasticity.Neurobiology of disease · 2026Review
- Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes.Annals of clinical and translational neurology · 2025Article
- Tenascin CNature communications · 2023Article
- Nephronectin as a Matrix Effector in Cancer.Cancers · 2021Review
- Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties.Development (Cambridge, England) · 2019Article
- Integrins promote axonal regeneration after injury of the nervous system.Biological reviews of the Cambridge Philosophical Society · 2018Review
- No Association Between rs7077361 in ITGA8 and Parkinson's Disease in Sweden.The open neurology journal · 2016Article
- Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.Journal of the American Society of Nephrology : JASN · 2015Article
- Extracellular matrix regulation of inflammation in the healthy and injured spinal cord.Experimental neurology · 2014Review
- Revisiting the matricellular concept.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Proregenerative properties of ECM molecules.BioMed research international · 2013Review
- Article
- Integrins as receptor targets for neurological disorders.Pharmacology & therapeutics · 2012Review
- How do tenascins influence the birth and life of a malignant cell?Journal of cellular and molecular medicine · 2012Review
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression.Development (Cambridge, England) · 2007Article
- Methods for identifying novel integrin ligands.Methods in enzymology · 2007Review
- Studies on integrins in the nervous system.Methods in enzymology · 2007Review
- Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
This paper identifies a neuronal receptor for tenascin-C (tenascin/cytotactin), an extracellular matrix protein that has previously been detected in developing sensory and motor neuron pathways and has been shown to regulate cell migration in the developing CNS. Antibodies specific for each subunit of the integrin alpha 8 beta 1 are used to demonstrate that alpha 8 beta 1 mediates neurite outgrowth of embryonic sensory and motor neurons on this extracellular matrix protein. In addition, expression of alpha 8 in K562 cells results in surface expression of alpha 8 beta 1 heterodimers that are shown to promote attachment of this cell line to tenascin. The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type III repeats 6-8.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.