ArticleThe Journal of physiology1995
Heterogeneity of neuronal nicotinic acetylcholine receptors in thin slices of rat medial habenula.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 48 citations in OpenAlex.
- Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.Behavioural brain research · 2022Article
- Neurobiological Mechanisms of Nicotine Reward and Aversion.Pharmacological reviews · 2022Review
- Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling.Neuropharmacology · 2020Review
- Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula.Neuropharmacology · 2009Article
- Interactions of atropine with heterologously expressed and native alpha 3 subunit-containing nicotinic acetylcholine receptors.British journal of pharmacology · 2003Article
- Clustering of nicotinic acetylcholine receptors: from the neuromuscular junction to interneuronal synapses.Molecular neurobiology · 2002Review
- Regulation of the sensitivity of acetylcholine receptors to nicotine in rat habenula neurons.The Journal of physiology · 2000Article
- Single channel properties of neuronal nicotinic ACh receptors in stratum radiatum interneurons of rat hippocampal slices.The Journal of physiology · 2000Article
- The subunit dominates the relaxation kinetics of heteromeric neuronal nicotinic receptors.The Journal of physiology · 2000Article
- Guinea-pig sympathetic neurons express varying proportions of two distinct P2X receptors.The Journal of physiology · 2000Article
- Identification of four classes of brain nicotinic receptors using beta2 mutant mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Functional contribution of the alpha5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones.The Journal of physiology · 1998Article
- Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Neuronal nicotinic acetylcholine receptors in slices of rat medial habenula were studied using patch clamp recording techniques. 2. Whole cell current responses to cytisine could be blocked by hexamethonium, as expected for nicotinic receptors. The whole cell current-voltage relations were linear at negative membrane potentials, but showed strong inward rectification when chloride currents were minimized. 3. When 1 mM Ca2+ (0 mM Mg2+) was present in the external recording solution, the single channel conductances elicited by acetylcholine or nicotine in twenty patches were in the range 39-58 pS, with a mean of 47 pS. There appeared to be at least two groups of conductances. 4. In the open point amplitude distributions of three patches, the most common amplitude corresponded to 41 pS (81% of the area). In another four patches the most common amplitude corresponded to a mean conductance of 51 pS (83% of the area). Direct transitions between open levels were rare. 5. Channel closed times were not significantly different for the two conductance groups. However, for the four patches with predominantly 51 pS openings, the means of the distributions of open times longer than two filter rise times averaged 5.8 ms. Those patches with predominantly 41 pS openings averaged 14 ms. Also, for patches with predominantly 51 pS openings the overall mean burst length was 5.8 ms, whereas for patches with predominantly 41 pS openings it was 16.1 ms. 6. These observations suggest that 51 and 41 pS openings result from the activity of at least two, but possibly more, different receptor subtypes. We conclude that nicotinic receptors in the rat ventral medial habenula are heterogeneous.
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