ArticleBritish journal of pharmacology1995
Cyclic GMP-mediated inhibition of L-type Ca2+ channel activity by human natriuretic peptide in rabbit heart cells.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 104 citations in OpenAlex.
- Ligand-Dependent Downregulation of Guanylyl Cyclase/Natriuretic Peptide Receptor-A: Role of miR-128 and miR-195.International journal of molecular sciences · 2022Article
- Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts.International journal of molecular sciences · 2022Review
- Electrophysiologic and molecular mechanisms of a frameshift NPPA mutation linked with familial atrial fibrillation.Journal of molecular and cellular cardiology · 2019Article
- Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.Journal of molecular and cellular cardiology · 2017Article
- Exogenous connexin43-expressing autologous skeletal myoblasts ameliorate mechanical function and electrical activity of the rabbit heart after experimental infarction.International journal of experimental pathology · 2015Article
- Involvement of Na+/K+ pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of α1c proteins.Experimental & molecular medicine · 2012Article
- Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Atrial natriuretic peptide regulates Ca channel in early developmental cardiomyocytes.PloS one · 2010Article
- Article
- Cardiac and vascular changes in cirrhosis: pathogenic mechanisms.World journal of gastroenterology · 2006Review
- Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.British journal of pharmacology · 2002Article
- Potentiation of slow component of delayed rectifier K(+) current by cGMP via two distinct mechanisms: inhibition of phosphodiesterase 3 and activation of protein kinase G.British journal of pharmacology · 2002Article
- Haeme oxygenase-1 and cardiac anaphylaxis.British journal of pharmacology · 2001Article
- Estrogen receptors activate atrial natriuretic peptide in the rat heart.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.The Journal of clinical investigation · 1998Article
- Regulation of myocardial calcium channels by cyclic AMP metabolism.Basic research in cardiology · 1996Review
- Regulation of slow calcium channels of myocardial cells and vascular smooth muscle cells by cyclic nucleotides and phosphorylation.Molecular and cellular biochemistry · 1994Review
- Cardiovascular changes in cirrhosis: pathogenesis and clinical implications.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
- Comparative study of cardiac electrophysiological effects of atrial natriuretic peptide.Molecular and cellular biochemistryArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Effects of atrial natriuretic peptide (ANP) on the L-type Ca2+ channels were examined in rabbit isolated ventricular cells by use of whole-cell and cell-attached configurations of the patch clamp methods. ANP produced a concentration-dependent decrease (10-100 nM) in amplitude of a basal Ca2+ channel current. 2. The inactive ANP (methionine-oxidized ANP, 30 nM) failed to decrease the current. 3. 8-Bromo-cyclic GMP (300 microM), a potent activator of cyclic GMP-dependent protein kinase (PKG), produced the same effects on the basal Ca2+ channel current as those produced by ANP. The cyclic GMP-induced inhibition of the Ca2+ channel current was still evoked in the presence of 1-isobutyl-3-methyl-xanthine, an inhibitor of phosphodiesterase. ANP failed to produce inhibition of the Ca2+ channel current in the presence of 8-bromo-cyclic GMP. 4. In the single channel recording, ANP and 8-bromo-cyclic GMP also inhibited the activities of the L-type Ca2+ channels. Both agents decreased the open probability (NPo) without affecting the unit amplitude. 5. The present results suggest that ANP inhibits the cardiac L-type Ca2+ channel activity through the intracellular production of cyclic GMP and then activation of PKG.
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