ArticleProceedings of the National Academy of Sciences of the United States of America1995
Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Lectin-Directed Protein Aggregation Therapy toward Hyperfucosylated and Hypersialylated Metastatic Colorectal Cancers.Biomaterials research · 2026Article
- Tumor-Associated Glycans as Targets for Immunotherapy: The Wistar Institute Experience/Legacy.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2021Review
- Article
- Cell-free enzymatic synthesis of GDP-L-fucose from mannose.AMB Express · 2019Article
- Gene expression profiling reveals upregulated FUT1 and MYBPC1 in children with pancreaticobiliary maljunction.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Identification of A Gene Set Associated with Colorectal Cancer in Microarray Data Using The Entropy Method.Cell journal · 2019Article
- Uncovering the Binding Specificities of Lectins with Cells for Precision Colorectal Cancer Diagnosis Based on Multimodal Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Profiling of different pancreatic cancer cells used as models for metastatic behaviour shows large variation in their N-glycosylation.Scientific reports · 2017Article
- High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma.Scientific reports · 2017Article
- Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.Cell death & disease · 2016Article
- Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review.Clinical reviews in allergy & immunology · 2015Review
- Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation.Arthritis research & therapy · 2014Article
- Associated expression of α2,3sialylated type 2 chain structures with lymph node metastasis in distal colorectal cancer.Surgery today · 2013Article
- α(1,2)fucosylation in human colorectal carcinoma.Oncology letters · 2010Article
- Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2007Article
- Expression of H type 1 antigen of ABO histo-blood group in normal colon and aberrant expressions of H type 2 and H type 3/4 antigens in colon cancer.Glycoconjugate journal · 2000Article
- Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases.Gut · 2000Article
- Inhibition of MT-450 rat mammary tumour growth by antibodies recognising subtypes of blood group antigen B.Oncogene · 1999Article
- Peptide mimotopes of carbohydrate antigens.Immunologic research · 1998Review
- Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells.The Biochemical journal · 1997Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase (EC 2.4.1.69) is a key enzyme in the biosynthesis of fucosylated type 1 and 2 lactoseries structures, such as Lewis b and the H type 2 and Lewis Y, respectively, that are accumulated in colon adenocarcinoma. Analysis of the mRNA transcript level for the human H gene-encoded beta-D-galactoside alpha-2-L-fucosyltransferase revealed 40- and 340-fold increases in the mRNA levels in all adenocarcinomas and tumor cell lines, respectively, compared to normal colon mucosa where a low level of mRNA transcript was detected. A variable increase in mRNA transcript levels was observed in 50% of adenomatous polyps. Nucleotide sequence analysis of the protein coding region of the cDNAs derived from normal colon, adenoma, and colon adenocarcinoma revealed 100% homology, suggesting that there are no tumor-associated allelic variations within the H beta-D-galactoside alpha-2-L-fucosyltransferase cDNA. These results suggest that beta-D-galactoside alpha-2-L-fucosyltransferase expression highly correlates with malignant progression of colon adenocarcinoma.
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Registered trials
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