Evidence map›Paper›PMID 7539782›Full record

ArticleJapanese journal of cancer research : Gann1995

Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7.

Y Hanazono, K Sasaki, H Odai, T Mimura, K Mitani, Y Yazaki, H Hirai

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Japanese journal of cancer research : Gann, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Y HanazonoThird Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
K Sasaki
H Odai
T Mimura
K Mitani
Y Yazaki
H Hirai
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vav proto-oncogene product (Vav) is expressed exclusively in hematopoietic cells and is reported to have guanine nucleotide exchange activity. Here we report that granulocyte-macrophage colony-stimulating factor, interleukin-3, and erythropoietin induce tyrosine phosphorylation of Vav in a human leukemia cell line UT-7. Tyrosine phosphorylation of Vav is rapid and transient; it occurs within 1 min of the stimulation and at physiological concentrations of the factors. Furthermore, we show that Vav is constitutively associated with the adapter molecule Grb2/Ash in UT-7. These data suggest that tyrosine kinases, the adapter Grb2/Ash, and the guanine nucleotide exchange factor Vav are members of a signaling pathway leading to Ras activation in hematopoietic cells.

Indexed as

Adaptor Proteins, Signal TransducingCell Cycle ProteinsAmino Acid SequenceErbB ReceptorsErythropoietinGranulocyte-Macrophage Colony-Stimulating FactorGRB2 Adaptor ProteinHumansInterleukin-3LeukemiaMolecular Sequence DataNeoplasm ProteinsPhosphorylationProteinsProtein-Tyrosine KinasesProto-Oncogene MasAdaptor Proteins, Signal TransducingCell Cycle ProteinsErbB ReceptorsErythropoietinGranulocyte-Macrophage Colony-Stimulating FactorGRB2 Adaptor ProteinGRB2 protein, humanInterleukin-3MAS1 protein, humanNeoplasm ProteinsProteinsProtein-Tyrosine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-vavProto-Oncogene Proteins pp60(c-src)ras ProteinsVAV1 protein, human

Identifiers

PMID7539782
PMCPMC5920837
OpenAlexW1964549183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.