ArticleThe Journal of experimental medicine1995
The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T cell, and macrophage recruitment.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies.Mediators of inflammation · 2003Pooled it
- Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways.Scientific reports · 2019Article
- Epidermal RAF prevents allergic skin disease.eLife · 2016Article
- An Overlook to the Characteristics and Roles Played by Eotaxin Network in the Pathophysiology of Food Allergies: Allergic Asthma and Atopic Dermatitis.Inflammation · 2016Review
- The role of chemokines in cutaneous immunosurveillance.Immunology and cell biology · 2015Review
- Expression of TNF-α and RANTES in drug-induced human gingival overgrowth.Indian journal of pharmacology · 2010Article
- Cellular aspects of atopic dermatitis.Clinical reviews in allergy & immunology · 2007Review
- Eosinophils and urticaria.Clinical reviews in allergy & immunology · 2006Review
- Chemokine networks in atopic dermatitis: traffic signals of disease.Current allergy and asthma reports · 2005Review
- Improvement of dermatitis by iontophoretically delivered antisense oligonucleotides for interleukin-10 in NC/Nga mice.Gene therapy · 2004Article
- Langerhans cells renew in the skin throughout life under steady-state conditions.Nature immunology · 2002Article
- CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation.The Journal of clinical investigation · 2002Article
- Regulation of allergic airways inflammation by cytokines and glucocorticoids.Current allergy and asthma reports · 2001Review
- Chemokine-induced cutaneous inflammatory cell infiltration in a model of Hu-PBMC-SCID mice grafted with human skin.The American journal of pathology · 2001Article
- Chemokines in the limbal form of vernal keratoconjunctivitis.The British journal of ophthalmology · 2000Article
- Increased levels in vivo of mRNAs for IL-8 and macrophage inflammatory protein-1 alpha (MIP-1 alpha), but not of RANTES mRNA in peripheral blood mononuclear cells of patients with atopic dermatitis (AD).Clinical and experimental immunology · 1999Article
- Article
- Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines.The Journal of clinical investigation · 1997Article
- Chemokines active on eosinophils: potential roles in allergic inflammation.The Journal of experimental medicine · 1996Review
- Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The C-C chemokines RANTES and monocyte chemotactic protein-3 (MCP-3) are potent chemoattractants in vitro for eosinophils and other cell types associated with allergic reactions. We tested the hypothesis that the allergen-induced infiltration of eosinophils, T cells, and macrophages in the skin of atopic subjects is accompanied by the appearance of mRNA+ cells for RANTES and MCP-3. Cryostat sections were obtained from skin biopsies from six subjects 6, 24, and 48 h after allergen challenge. Tissue was processed for immunocytochemistry (ICC) and for in situ hybridization using 35S-labeled riboprobes for RANTES and MCP-3. In contrast to diluent controls, allergen provoked a significant increase in mRNA+ cells for MCP-3, which peaked at 6 h and progressively declined at 24 and 48 h. This paralleled the kinetics of total (major basic protein positive [MBP]+) and activated (cleaved form of eosinophil cationic protein [EG2]+) eosinophil infiltration. The allergen-induced expression of cells mRNA+ for RANTES was also clearly demonstrable at 6 h. However, the numbers were maximal at 24 h and declined slightly at the 48-h time point. The number of mRNA+ cells for RANTES paralleled the kinetics of infiltration of CD3+, CD4+, and CD8+ T cells whereas the number of CD68+ macrophages was still increasing at 48 h. These data support the view that MCP-3 is involved in the regulation of the early eosinophil response to specific allergen, whereas RANTES may have more relevance to the later accumulation of T cells and macrophages.
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