ArticleProceedings of the National Academy of Sciences of the United States of America1995
Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- JAK inhibition in PD-1 immunotherapy and tumor microenvironment.Frontiers in immunology · 2026Review
- JAK-STAT Signaling in Autoimmunity and Cancer.ImmunoTargets and therapy · 2025Review
- Review
- The JAK/STAT signaling pathway: from bench to clinic.Signal transduction and targeted therapy · 2021Review
- Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.The Journal of clinical investigation · 2017Article
- EGFR Signaling Regulates Maspin/SerpinB5 Phosphorylation and Nuclear Localization in Mammary Epithelial Cells.PloS one · 2016Article
- LIF-STAT signaling and trophoblast biology.JAK-STAT · 2013Review
- Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Origins of growth factors: NGF and EGF.The Journal of biological chemistry · 2008Article
- Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells.Journal of molecular biology · 2008Article
- Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.The Journal of cell biology · 2003Article
- Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function.Journal of virology · 2002Article
- Hepatitis B virus and hepatocellular carcinoma.International journal of experimental pathology · 2001Review
- ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation.The Journal of cell biology · 1999Article
- Integrin-mediated adhesion of endothelial cells induces JAK2 and STAT5A activation: role in the control of c-fos gene expression.Molecular biology of the cell · 1999Article
- STAT signaling in the pathogenesis and treatment of cancer.Molecular medicine (Cambridge, Mass.) · 1999Review
- Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis.Oncogene · 1999Article
- Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.Molecular and cellular biology · 1999Article
- Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.The Journal of clinical investigation · 1998Article
- Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Intraperitoneal injection of epidermal growth factor into mice results in the appearance of multiple tyrosine-phosphorylated proteins in liver nuclei within minutes after administration. We have previously identified three of these proteins as Stat 1 alpha, Stat 1 beta (p91, p84), and Stat 3 (p89). In the present report we demonstrate that Stat 5 (p92), the recently described prolactin inducible transcription factor detected in mammary glands, is the major tyrosine-phosphorylated protein translocated to the nucleus in mouse liver in response to epidermal growth factor. Furthermore, gel-shift analysis and affinity purification revealed that Stat 5, Stat 1 alpha, and Stat 1 beta specifically bind to the prolactin inducible element upstream of the beta-casein promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.