ArticleClinical and experimental immunology1995
Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Transcription factor C/EBPα is required for the development of Ly6CProceedings of the National Academy of Sciences of the United States of America · 2024Article
- In-silico identification and prioritization of therapeutic targets of asthma.Scientific reports · 2023Article
- Article
- Immune Phenotyping of Patients With Acute Vogt-Koyanagi-Harada Syndrome Before and After Glucocorticoids Therapy.Frontiers in immunology · 2021Article
- Review
- M2 Monocyte Microparticles Are Increased in Intracerebral Hemorrhage.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2017Observational
- CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Beryllium increases the CD14(dim)CD16+ subset in the lung of chronic beryllium disease.PloS one · 2015Article
- Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.Epigenetics · 2014Article
- Sources of heterogeneity in human monocyte subsets.Immunology letters · 2013Article
- Endobiogeny: a global approach to systems biology (part 2 of 2).Global advances in health and medicine · 2013Review
- Collaborating with the enemy: function of macrophages in the development of neoplastic disease.Mediators of inflammation · 2013Review
- Article
- ADAM8: a new therapeutic target for asthma.Expert opinion on therapeutic targets · 2009Review
- Impaired Toll-like receptor 2 signalling in monocytes from 5-year-old allergic children.Clinical and experimental immunology · 2009Article
- Longitudinal analysis of activation markers on monocyte subsets during the development of simian immunodeficiency virus encephalitis.Journal of neuroimmunology · 2006Article
- Haemodialysis monocytopenia: differential sequestration kinetics of CD14+CD16+ and CD14++ blood monocyte subsets.Clinical and experimental immunology · 2001Article
- Surface phenotype analysis of CD16+ monocytes from leukapheresis collections for peripheral blood progenitors.Clinical and experimental immunology · 1999Article
- Expanded CD14+ CD16+ monocyte subpopulation in patients with acute and chronic infections undergoing hemodialysis.Infection and immunity · 1998Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway macrophages are activated in asthmatic subjects. Peripheral blood monocytes from these subjects present some functional features of activation, but their membrane markers are not known. Recently a new subtype of blood monocytes, CD14+/CD16+, has been identified which possesses the characteristics of tissue macrophages. A study was carried out on nine normal subjects and 11 untreated asthmatics having variable severities of the disease to examine the phenotypic characteristics of monocytes. CD14, CD16, HLA-DR, CD11a, CD11b, CD44 and CD54 were studied using double fluorescence flow cytometry since these antigens have been defined in the CD14+/CD16+ monocytes. The functional activation of monocytes was examined using the release of superoxide anion. The co-expression of CD14 and CD16 by monocytes in terms of percentage and mean fluorescence intensity was significantly higher in asthmatics (P < 0.002 and P < 0.0001, respectively, Mann-Whitney U-test). There was no difference for the other membrane markers between asthmatics and normal subjects. Superoxide anion release was significantly increased in asthmatic subjects (P < 0.01). This study shows that most blood monocytes of asthmatics are CD14+/CD16+ and are likely to present features of tissue macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.