ArticleClinical and experimental immunology1995
Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa--implications for pathogenesis.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 141 citations in OpenAlex.
- Origin and Function of Monocytes in Inflammatory Bowel Disease.Journal of inflammation research · 2024Review
- Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model.Functional & integrative genomics · 2022Article
- Preliminary Evidence of Differentially Induced Immune Responses by Microparticle-adsorbed LPS in Patients with Crohn's Disease.Journal of cellular immunology · 2022Article
- Increased monocyte abundance as a marker for relapse after discontinuation of biologics in inflammatory bowel disease with deep remission.Frontiers in immunology · 2022Article
- Article
- Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis.European journal of clinical pharmacology · 2020Article
- Article
- Can a Conversation Between Mesenchymal Stromal Cells and Macrophages Solve the Crisis in the Inflamed Intestine?Frontiers in pharmacology · 2018Review
- Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n-butyrate.Immunity, inflammation and disease · 2017Article
- Diversity and functions of intestinal mononuclear phagocytes.Mucosal immunology · 2017Review
- Intestinal Mononuclear Phagocytes in Health and Disease.Microbiology spectrum · 2017Review
- Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases.Clinical immunology (Orlando, Fla.) · 2016Review
- A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease.Journal of gastroenterology · 2015Review
- Diversity of Intestinal Macrophages in Inflammatory Bowel Diseases.Frontiers in immunology · 2015Review
- Lack of CD47 on donor hepatocytes promotes innate immune cell activation and graft loss: a potential barrier to hepatocyte xenotransplantation.Cell transplantation · 2014Article
- Human β defensin-3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV-infected persons.Immunology · 2013Article
- CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF.The Journal of experimental medicine · 2013Article
- Peripheral monocyte functions and activation in patients with quiescent Crohn's disease.PloS one · 2013Article
- The effects of oral and enteric Campylobacter concisus strains on expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 cells.PloS one · 2013Article
- A subset of human uterine endometrial macrophages is alternatively activated.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipopolysaccharide (LPS) is abundant in the intestinal lumen. CD14 is the receptor for the LPS-LPS binding protein complex, and its presence on mononuclear phagocytes allows cell activation by pg/ml concentrations of LPS. We have shown that the recently recruited blood monocyte in inflammatory bowel disease mucosa is CD14+. This study examined the expression of CD14 on macrophages in inflamed (n = 13) and uninflamed (n = 7) intestine by immunohistochemistry, and on disaggregated lamina propria mononuclear cells (12 from inflamed, 17 from uninflamed intestine) and peripheral blood mononuclear cells (n = 26) by flow cytometry, using a panel of three MoAbs directed against CD14. Immunohistochemistry revealed that 3.7% of macrophages in uninflamed intestine were CD14+, while 25.1% of macrophages in active inflammatory bowel disease expressed CD14 (P < 0.02). Flow cytometry demonstrated that CD14 expression by macrophages from Crohn's disease and ulcerative colitis was augmented significantly (P = 0.02 and P = 0.01, respectively) compared with uninflamed intestine, with a discrete population of macrophages in inflammatory bowel disease, not present in normal intestine, which strongly expressed CD14. The characteristically high levels of CD14 on blood monocytes were unaffected by the presence of intestinal inflammation. Given the exposure of lamina propria cells to LPS present in the lumen of the terminal ileum and colon, the increased numbers of CD14+ macrophages in inflammatory bowel disease may result in greatly increased production of inflammatory mediators, thereby suggesting a mechanism for the perpetuation of mucosal inflammation.
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