ArticleThe Journal of physiology1994
Voltage-clamp analysis of gap junctions between embryonic muscles in Drosophila.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Multilayer control of KaiR1D-autoreceptor function by the auxiliary protein Neto.bioRxiv : the preprint server for biology · 2025Article
- Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo.Nature communications · 2024Article
- scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development.Developmental cell · 2024Article
- Selective Disruption of Synaptic BMP Signaling by a Smad Mutation Adjacent to the Highly Conserved H2 Helix.Genetics · 2020Article
- Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila.Developmental biology · 2019Article
- Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at theeLife · 2018Article
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- A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction.PLoS genetics · 2016Article
- Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction.PLoS genetics · 2015Article
- Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction.PLoS genetics · 2015Article
- miR-8 controls synapse structure by repression of the actin regulator enabled.Development (Cambridge, England) · 2014Article
- Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction.Genes & development · 2012Article
- Article
- High resolution map of Caenorhabditis elegans gap junction proteins.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- UNC-1 regulates gap junctions important to locomotion in C. elegans.Current biology : CB · 2007Article
- Two Drosophila innexins are expressed in overlapping domains and cooperate to form gap-junction channels.Molecular biology of the cell · 2000Article
- Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient Ca2+ increases and by cAMP.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Review
- Longitudinal body wall muscles are electrically coupled across the segmental boundary in the third instar larva of Drosophila melanogaster.Invertebrate neuroscience : IN · 1996Article
- Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Intercellular communication between embryonic muscle fibres was examined in Drosophila melanogaster. 2. Injection of fluorescent dye revealed extensive coupling between muscle fibres which form a uniform communicating arrangement of cells without restriction at the segmental borders. 3. Dye transfer was blocked by octanol and membrane depolarization suggesting that it is mediated by gap junctions. 4. Double voltage-clamp experiments from cell pairs in situ showed that the ionic coupling is sensitive to the voltage difference between the cytoplasm and the extracellular space (transmembrane voltage, Vi-o) as well as between the cells (transjunctional voltage, Vj). 5. In steady-state conditions, the gap conductance (gj) was maximal for hyperpolarized Vi-o and decreased progressively to near zero as Vi-o became more positive than -50 mV. 6. Gap conductance decreased from a maximal value as Vj increased either in the positive or negative direction (by depolarizing or hyperpolarizing, respectively, one of the cells from a holding potential of -60 mV). In both cases, gj asymptotically approached a non-zero residual value which was different for negative and positive Vj (about 20% of the maximal conductance for negative transmembrane potentials and 10% for positive values). 7. Application of octanol (1 mM) resulted in an almost complete and reversible block of gj.
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