ArticleThe Journal of clinical investigation1995
Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 126 citations in OpenAlex.
- Nitric oxide and salt resistance in Dahl rats: no role of inducible NO synthase.Physiological research · 2023Article
- Shifting Paradigm from Gene Expressions to Pathways Reveals Physiological Mechanisms in Blood Pressure Control in Causation.International journal of molecular sciences · 2023Article
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- African Americans, hypertension and the renin angiotensin system.World journal of cardiology · 2014Review
- Mitochondrial polymorphisms in rat genetic models of hypertension.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
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- Inhibition of inducible nitric oxide synthase during high dietary salt intake.American journal of hypertension · 2002Article
- Fluxes and metabolic pools as model traits for quantitative genetics. I. The L-shaped distribution of gene effects.Genetics · 1999Article
- Linkage mapping of rat chromosome markers generated from chromosome-sorted DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Inducible nitric oxide synthase in the cardiovascular system.Heart (British Cardiac Society) · 1996Article
- Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.The Journal of clinical investigation · 1996Article
- Linkage mapping of the neuronal nitric oxide synthase gene (Nos1) to rat chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Alleles of the inducible nitric oxide synthase locus (Nos2) cosegregated highly significantly (P < 0.0001) with blood pressure in an F2 population [F2(S x MNS), n = 171] derived from a cross of inbred Dahl salt-sensitive (S) rats with Milan normotensive rats (MNS). In contrast, alleles at the constitutive brain nitric oxide synthase locus (Nos1) did not cosegregate with blood pressure in several F2 populations. Nos2 was mapped on rat chromosome 10. Nine genetic markers, including the angiotensin-converting enzyme (Ace) and Nos2 loci spanning roughly 46 cM on rat chromosome 10, all cosegregated strongly with blood pressure in the F2(S x MNS) population. Nos2 showed the highest LOD score of 6.3. Ace and Nos2 are 30 cM apart. In an F2 population [F2(S x WKY), n = 159] derived from a cross of S rats with Wistar-Kyoto (WKY) rats, Nos2 alleles did (P = 0.0070), but Ace alleles did not (P = 0.91), cosegregate with blood pressure. We conclude that the Nos2 locus rather than the Nos1 locus is a candidate for influencing blood pressure in the S rat. There are probably two separate but linked quantitative trait loci (QTL) for blood pressure on rat chromosome 10, one marked by Ace and the other marked by Nos2. In F2(S x MNS) functionally variant alleles at both QTL influence blood pressure, but in F2(S x WKY) only the QTL marked by Nos2 is segregating alleles influencing blood pressure.
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