ArticleBritish journal of pharmacology1995
Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Crotoxin fromFrontiers in immunology · 2026Article
- Molecular interaction assaysThe journal of venomous animals and toxins including tropical diseases · 2025Article
- Fraction ofThe journal of venomous animals and toxins including tropical diseases · 2024Article
- Review
- The anti-inflamatory effect of Andira anthelmia lectin in rats involves inhibition of the prostanoid pathway, TNF-α and lectin domain.Molecular biology reports · 2022Article
- Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids.Biomolecules · 2020Article
- Article
- Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties.The journal of venomous animals and toxins including tropical diseases · 2018Review
- Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides.PloS one · 2014Article
- Effects of Canavalia lectins on acute inflammation in sensitized and non-sensitized rats.Inflammation · 2013Article
- Purification and biological activities of Abelmoschus esculentus seed lectin.The protein journal · 2012Article
- Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds.Molecules (Basel, Switzerland) · 2012Article
- Vasodilator effects of Diocleinae lectins from the Canavalia genus.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Modulation of acute inflammation by a chitin-binding lectin from Araucaria angustifolia seeds via mast cells.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- The pharmacological profile of ovalbumin-induced paw oedema in rats.Mediators of inflammation · 2002Article
- Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment.Mediators of inflammation · 1999Article
- Anti-inflammatory effect of glucose-mannose binding lectins isolated from Brazilian beans.Mediators of inflammation · 1997Article
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9 authors.
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Abstract
1. The effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 mg/paw), compound 48/80 (3 micrograms/paw) and 5-hydroxytryptamine (5-HT) (3 micrograms/paw) in the rat hind-paw. The effects of crotapotin on platelet aggregation, mast cell degranulation and eicosanoid release from guinea-pig isolated lung were also investigated. 2. Subplantar co-injection of crotapotin (1 and 10 micrograms/paw) with carrageenin or injection of crotapotin (10 micrograms/paw) into the contralateral paw significantly inhibited the carrageenin-induced oedema. This inhibition was also observed when crotapotin (10-30 micrograms/paw) was administered either intraperitoneally or orally. Subplantar injection of heated crotapotin (15 min at 60 degrees C) failed to inhibit carrageenin-induced oedema. Subplantar injection of crotapotin (10 micrograms/paw) also significantly inhibited the rat paw oedema induced by compound 48/80, but it did not affect 5-HT-induced oedema. 3. In adrenalectomized animals, subplantar injection of crotapotin markedly inhibited the oedema induced by carrageenin. The inhibitory effect of crotapotin was also observed in rats depleted of histamine and 5-HT stores. 4. Crotapotin (30 micrograms/paw) had no effect on either the histamine release induced by compound 48/80 in vitro or on the platelet aggregation induced by both arachidonic acid (1 nM) and platelet activating factor (1 microM) in human platelet-rich plasma. The platelet aggregation and thromboxane B2 (TXB2) release induced by thrombin (100 mu ml-1) in washed human platelets were also not affected by crotapotin. In addition, crotapotin (10 microg/paw) did not affect the release of 6-oxo-prostaglandin Fla, and TXB2 induced by ovalbumin in sensitized guinea-pig isolated lungs.5. Our results indicate that the anti-inflammatory activity of crotapotin is not due to endogenous corticosteroid release or inhibition of cyclo-oxygenase activity. It is possible that crotapotin may interact with extracellular PLA2 generated during the inflammatory process thereby reducing its hydrolytic activity.
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