ArticleThe Journal of cell biology1995
Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- The Lego hypothesis of tissue morphogenesis: stereotypic organization of parallel orientational cell adhesions for epithelial self-assembly.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Desmosome and Hemidesmosome Disassembly in Retinal Pigmented Epithelium: Intersection with the Exosome Pathway.Advances in experimental medicine and biology · 2025Review
- Epigenetic Regulation of EMP/EMT-Dependent Fibrosis.International journal of molecular sciences · 2024Review
- Article
- miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1.Annals of translational medicine · 2019Article
- Overview of the Muscle Cytoskeleton.Comprehensive Physiology · 2017Review
- The Apical Localization of NaFrontiers in physiology · 2016Article
- Plasma membrane protein polarity and trafficking in RPE cells: past, present and future.Experimental eye research · 2014Review
- Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.Journal of ophthalmology · 2014Review
- A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis.Nature reviews. Cancer · 2013Review
- Hyperactivation of retina by light in mice leads to photoreceptor cell death mediated by VEGF and retinal pigment epithelium permeability.Cell death & disease · 2013Article
- Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat.Fluids and barriers of the CNS · 2013Article
- Rab25 regulates integrin expression in polarized colonic epithelial cells.Molecular biology of the cell · 2013Article
- Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- RPE barrier breakdown in diabetic retinopathy: seeing is believing.Journal of ocular biology, diseases, and informatics · 2011Article
- AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.The Journal of biological chemistry · 2011Article
- Epithelial phenotype and the RPE: is the answer blowing in the Wnt?Progress in retinal and eye research · 2008Review
- Sodium pump localization in epithelia.Journal of bioenergetics and biomembranes · 2007Review
- Fate of E-cadherin in early RPE cultures: transient accumulation of truncated peptides at nonjunctional sites.Investigative ophthalmology & visual science · 2006Article
- An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A primary function of cadherins is to regulate cell adhesion. Here, we demonstrate a broader function of cadherins in the differentiation of specialized epithelial cell phenotypes. In situ, the rat retinal pigment epithelium (RPE) forms cell-cell contacts within its monolayer, and at the apical membrane with the neural retina; Na+, K(+)-ATPase and the membrane cytoskeleton are restricted to the apical membrane. In vitro, RPE cells (RPE-J cell line) express an endogenous cadherin, form adherens junctions and a tight monolayer, but Na+,K(+)-ATPase is localized to both apical and basal-lateral membranes. Expression of E-cadherin in RPE-J cells results in restriction and accumulation of both Na+,K(+)-ATPase and the membrane cytoskeleton at the lateral membrane; these changes correlate with the synthesis of a different ankyrin isoform. In contrast to both RPE in situ and RPE-J cells that do not form desmosomes, E-cadherin expression in RPE-J cells induces accumulation of desmoglein mRNA, and assembly of desmosome-keratin complexes at cell-cell contacts. These results demonstrate that cadherins directly affect epithelial cell phenotype by remodeling the distributions of constitutively expressed proteins and by induced accumulation of specific proteins, which together lead to the generation of structurally and functionally distinct epithelial cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.