ArticleIn vitro cellular & developmental biology. Animal1995
HH2A, an immortalized bovine mammary epithelial cell line, expresses the gene encoding mammary derived growth inhibitor (MDGI).
Article in In vitro cellular & developmental biology. Animal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Development and validation of immortalized bovine mammary epithelial cell line as an in vitro model for the study of mammary gland functions.Cytotechnology · 2018Article
- Can widely used cell type markers predict the suitability of immortalized or primary mammary epithelial cell models?Biological research · 2016Article
- Novel target for peptide-based imaging and treatment of brain tumors.Molecular cancer therapeutics · 2014Article
- Bovine mammary epithelial cell cultures for the study of mammary gland functions.In vitro cellular & developmental biology. Animal · 2014Article
- Establishment and characterization of a lactating dairy goat mammary gland epithelial cell line.In vitro cellular & developmental biology. Animal · 2012Article
- Establishment and characterization of a buffalo (Bubalus bubalis) mammary epithelial cell line.PloS one · 2012Article
- Fatty acid metabolism in human breast cancer cells (MCF7) transfected with heart-type fatty acid binding protein.Molecular and cellular biochemistry · 1999Article
- Establishment and characterization of a bovine mammary epithelial cell line with unique properties.In vitro cellular & developmental biology. Animal · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
We have established and partially characterized a spontaneously immortalized bovine mammary epithelial cell line, designated HH2a. The cells express the gene encoding for mammary derived growth inhibitor (MDGI) when grown on released collagen gels in the presence of lactogenic hormones. This is the first report of a cell line that expresses MDGI. Immunohistochemical studies showed that HH2a cells contain keratin intermediate filaments and desmosomes. When plated on confluent monolayer of live fibroblasts, HH2a cells extensively contacted with fibroblasts. When embedded in the collagen gels, they rearranged themselves to produce three-dimensional duct-like outgrowths extending into the matrix. The HH2a cell line should be useful in investigations of the roles of cell-cell and cell-extracellular interactions in regulation of breast epithelial cell proliferation, and of the hormonal regulation of MDGI gene expression.
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