ArticleVirchows Archiv : an international journal of pathology1995
Increased numbers of cytokeratin-positive interstitial reticulum cells (CIRC) in reactive, inflammatory and neoplastic lymphadenopathies: hyperplasia or induced expression?
Article in Virchows Archiv : an international journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 76 citations in OpenAlex.
- Fibroblastic/cytokeratin-positive interstitial reticular cell tumor of the spleen with indolent behavior: a case report with review of the literature.Virchows Archiv : an international journal of pathology · 2023Review
- Article
- Genetic analysis of single disseminated tumor cells in the lymph nodes and bone marrow of patients with head and neck squamous cell carcinoma.Molecular oncology · 2022Article
- Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type.Diagnostic pathology · 2020Article
- Extra-nodal Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma Presenting as a Colonic Polyp: Report of a Rare Case with Review of Literature.Journal of gastrointestinal cancer · 2020Review
- Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis.British journal of cancer · 2018Article
- [Tumors of dendritic and other accessory cells of lymph nodes].Der Pathologe · 2015Review
- Micrometastasis of hypopharyngeal cancer.Langenbeck's archives of surgery · 2014Article
- Immunohistochemistry, a valuable tool in detection of cervical lymph node micrometastases in head and neck squamous cell carcinoma: a prospective study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2013Article
- Accuracy of a nomogram for prediction of lymph-node metastasis detected with conventional histopathology and ultrastaging in endometrial cancer.British journal of cancer · 2013Article
- Physiological and pathological role of local and immigrating colonic stem cells.World journal of gastroenterology · 2012Review
- Isolated lymphoid follicles in colon: switch points between inflammation and colorectal cancer?World journal of gastroenterology · 2011Article
- The possible role of isolated lymphoid follicles in colonic mucosal repair.Pathology oncology research : POR · 2010Review
- The human keratins: biology and pathology.Histochemistry and cell biology · 2008Review
- Does immunostaining effectively upstage colorectal cancer by identifying micrometastatic nodal disease?International journal of colorectal disease · 2007Article
- Multimarker RT-PCR assay for the detection of minimal residual disease in sentinel lymph nodes of breast cancer patients.British journal of cancer · 2006Article
- Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.Cancer research · 2006Article
- Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer.World journal of gastroenterology · 2005Article
- Multiparameter flow cytometry as a tool for the detection of micrometastatic tumour cells in the sentinel lymph node procedure of patients with breast cancer.Journal of clinical pathology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 291 enlarged lymph nodes showing a range of reactive-inflammatory processes, primary and metastatic neoplasms were studied to determine the distribution and immunoprofile of their cytokeratin-positive interstitial reticulum cells (CIRC) in comparison with normal nodes. In 258/291 nodes (89%), CIRC numbers were distinctly increased in the subcapsular, paracortical and, occasionally, in the medullary zones; often, these increased CIRC formed networks around follicles, sinuses and vessels. CIRC had comparatively small, irregularly shaped bodies and dendritic processes; occasionally, giant forms were noted. CIRC contained cytokeratins (CK) 8 and 18 but not 19, as shown by immunohistochemistry, and by gel electrophoresis with subsequent immunoblotting. They co-expressed vimentin consistently, alpha-smooth-muscle actin frequently, and desmin less frequently. They did not contain desmoplakins, Factor VIII, S-100, LCA, B and T lymphocyte- and macrophage-associated antigens, chromogranin A, synaptophysin or the A-80 glycoprotein. We found no clear correlation between the increased CIRC and given nodal disease processes. However, CIRC were most abundant in nodes free of but draining malignant tumours; bizarre CIRC assemblies were noted in HIV lymphadenopathy. CIRC appear to represent a subset of the so-called "fibroblastic reticulum cells" of lymph nodes. Their function remains undetermined; their increase in diverse lymphadenopathies suggests that they partake in nodal reactions to injury. It remains unclear whether the increase in CIRC relative number is due to proliferation or to CK gene induction processes but their presence and potential capability to undergo hyperplasia with dysplastic forms should alert pathologists to possible diagnostic pitfalls. In addition, we discuss that CIRC may undergo transformation and represent the "cell of origin" of certain CK-positive tumours restricted to lymph nodes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.